Meralluride | CAS#8069-64-5

MedKoo Cat#: 534821 | Name: Meralluride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Meralluride is a bioactive chemical.

Chemical Structure

Meralluride

CAS#8069-64-5

Theoretical Analysis

MedKoo Cat#: 534821

Name: Meralluride

CAS#: 8069-64-5

Chemical Formula: C16H23HgN6NaO8

Exact Mass: 652.1181

Molecular Weight: 650.97

Elemental Analysis: C, 29.52; H, 3.56; Hg, 30.81; N, 12.91; Na, 3.53; O, 19.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Meralluride

IUPAC/Chemical Name

Mercury, (3-((((3-carboxy-1-oxopropyl)amino)carbonyl)amino)-2-methoxypropyl)hydroxy-, monosodium salt, mixt. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

InChi Key

GCPBDDBJRFCDMG-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H15N2O5.C7H8N4O2.Hg.Na.O/c1-6(16-2)5-10-9(15)11-7(12)3-4-8(13)14;1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;;;/h6H,1,3-5H2,2H3,(H,13,14)(H2,10,11,12,15);3H,1-2H3,(H,8,9);;;/q;;;+1;-1

SMILES Code

[O-][Hg]CC(OC)CNC(NC(CCC(O)=O)=O)=O.O=C(N1C)N(C)C2=C(NC=N2)C1=O.[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 650.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Siegel W, Gifford RW Jr. Efficacy of ethacrynic acid in patients with refractory congestive heart failure resistant to meralluride. Am J Cardiol. 1968 Aug;22(2):260-5. doi: 10.1016/0002-9149(68)90232-4. PMID: 5665857. 2: MAREN TH. Carbonic anhydrase inhibition. VIII. Lack of renal response to acetazolamide and to meralluride in a dog with chronic nephritis. J Chronic Dis. 1958 Aug;8(2):195-201. doi: 10.1016/0021-9681(58)90191-7. PMID: 13563602. 3: Capelli JP, Wesson LG Jr, Aponte GE. Response of kidney and salivary gland G-6-PD and renin to adrenalectomy, angiotensin, bradykinin and meralluride. Clin Sci. 1969 Dec;37(3):707-14. PMID: 4312148. 4: SANABRIA A. Ultrastructural changes produced in the rat kidney by a mercurial diuretic (meralluride). Br J Pharmacol Chemother. 1963 Apr;20(2):352-61. doi: 10.1111/j.1476-5381.1963.tb01474.x. PMID: 13976179; PMCID: PMC1703643. 5: KESSLER RH, LOZANO R, PITTS RF. A comparison of the pharmacological behavior of chlormerodrin, meralluride, mersalyl and mercuric chloride in the dog. J Pharmacol Exp Ther. 1957 Dec;121(4):432-42. PMID: 13492158. 6: MOYER JH, HANDLEY CA, SEIBERT RA. An analysis of the excretory products of a mercurial diuretic (meralluride) by column chromatography. Ann N Y Acad Sci. 1957 Apr 11;65(5):511-9. doi: 10.1111/j.1749-6632.1956.tb36656.x. PMID: 13411947. 7: Jones VD, Landon EJ. The effect of ouabain, meralluride and ethacrynic acid on respiration and glycolysis in kidney slices. Biochem Pharmacol. 1967 Nov;16(11):2163-9. doi: 10.1016/0006-2952(67)90015-9. PMID: 4229545. 8: WHITE HL, ROLF D. AN ANALYSIS OF THE EFFECTS OF MERALLURIDE AND OUABAIN ON SODIUM EXCRETION BY STOP-FLOW AND SLOW-FLOW TECHNIQUES. J Pharmacol Exp Ther. 1963 Sep;141:326-32. PMID: 14064195. 9: MARSH R, GREINER T, GOLD H, MATHES S, PALUMBO F, WARSHAW L, WEAVER J. A comparison of the diuretic effects of mercuhydrin (meralluride) administered by several routes. N Engl J Med. 1952 Oct 16;247(16):593-6. doi: 10.1056/NEJM195210162471602. PMID: 12993275. 10: MOYER JH, SEIBERT RA, HANDLEY CA. Chromatography studies of the excretion products after meralluride administration in normal subjects and cardiac patients. Circ Res. 1957 Sep;5(5):493-7. doi: 10.1161/01.res.5.5.493. PMID: 13461280. 11: MAREN TH. Carbonic anhydrase inhibition. IX. Augmentation of the renal effect of meralluride by acetazolamide. J Pharmacol Exp Ther. 1958 Aug;123(4):311-5. PMID: 13564411. 12: LEVOKOVE E, SARROW LA. Treatment of chronic congestive heart failure with a new meralluride (mercuhydrin) suppository. N Y State J Med. 1951 Jun 1;51(11):1410-2. PMID: 14853106. 13: Weisberg H, Strobos RJ, Rosenthal WS, Appleton HD, Glass GB. The comparative effect of chlorothiazide and meralluride on the development of hepatic encephalopathy in cirrhotic patients. Gastroenterologia. 1966;105(6):321-34. doi: 10.1159/000202062. PMID: 5958596. 14: BIZARD G, VANLERENBERGHE J, GUERRIN F, ROBELET A, MILBLED G. Secrétion de bile par le foie de rat. IV. Action de la meralluride [Bile secretion by the rat liver. IV. Effect of meralluride]. J Physiol (Paris). 1958 Mar;50(2):157-9. French. PMID: 13550101. 15: BATTERMAN RC. The comparative diuretic effectiveness of mercumatilin and meralluride with and without concomitant administration of ammonium chloride. Am Heart J. 1954 Nov;48(5):780-4. doi: 10.1016/0002-8703(54)90069-1. PMID: 13197303. 16: Konikowski T, Haynie TP. The effect of meralluride blocking on localization of radiochlormerodrin in a mouse brain tumor (Sarcoma). Int J Appl Radiat Isot. 1970 Dec;21(12):711-8. doi: 10.1016/0020-708x(70)90080-3. PMID: 5505012. 17: MEYER OO, KURTH DM. The subcutaneous administration of mercuhydrin (meralluride sodium solution). Wis Med J. 1950 Oct;49(10):904-6. PMID: 14782497. 18: GOLD H, KWIT NT, MESSELOFF CR, KRAMER ML, GOLFINOS AJ, MEHTA D, ZAHM W, WARSHAW L. Comparison of hydroflumethiazide and meralluride. New method for quantitative assay of diuretics in bedfast patients with edema. JAMA. 1961 Jul 29;177:239-42. doi: 10.1001/jama.1961.03040300011003. PMID: 13706413. 19: HANDLEY CA, SEIBERT RA. Chromatographic fractionation of the urinary excretory products from meralluride. J Pharmacol Exp Ther. 1956 Jul;117(3):253-7. PMID: 13332570. 20: Gold H, Mehta D, Kwit NT, Messeloff CR, Golfinos AJ, Zahm WN, Bross ID. Relative diuretic potential of intramuscular meralluride and oral hydrochlorothiazide in patients with edema. J Clin Pharmacol J New Drugs. 1970 Mar-Apr;10(2):88-94. doi: 10.1177/009127007001000203. PMID: 5264344.