MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 591960 | Name: Alloxan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alloxan is an acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.

Chemical Structure

Alloxan
CAS#50-71-5 (free base)

Theoretical Analysis

MedKoo Cat#: 591960

Name: Alloxan

CAS#: 50-71-5 (free base)

Chemical Formula: C4H2N2O4

Exact Mass: 142.0015

Molecular Weight: 142.07

Elemental Analysis: C, 33.82; H, 1.42; N, 19.72; O, 45.05

Price and Availability

Size Price Availability Quantity
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
50-71-5 (free base) 2244-11-3 (monohydrate) 6010-91-9 (tetrahydrate)
Synonym
Alloxan; NSC 7169; NSC-7169; NSC7169
IUPAC/Chemical Name
2,4,5,6(1H,3H)-Pyrimidinetetrone
InChi Key
HIMXGTXNXJYFGB-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H2N2O4/c7-1-2(8)5-4(10)6-3(1)9/h(H2,5,6,8,9,10)
SMILES Code
O=C1NC(C(C(N1)=O)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 142.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin H, Zheng M, Mao X, Feng X, Li J, Rao G, Lin F. Oxytocin treatment prevents marrow adiposity observed in alloxan-induced diabetic rabbits using proton MR spectroscopy. Endokrynol Pol. 2018 Jun 28. doi: 10.5603/EP.a2018.0040. [Epub ahead of print] PubMed PMID: 29952410. 2: Kato Y, Masago Y, Kondo C, Yogo E, Torii M, Hishikawa A, Izawa T, Kuwamura M, Yamate J. Comparison of Acute Gene Expression Profiles of Islet Cells Obtained via Laser Capture Microdissection between Alloxan- and Streptozotocin-treated Rats. Toxicol Pathol. 2018 Jan 1:192623318783957. doi: 10.1177/0192623318783957. [Epub ahead of print] PubMed PMID: 29929439. 3: Yan YQ, Dai GH, Jiang SP, Lu Y, Tong YP, Wang P. [Effect of two kinds of fermented food on blood glucose and lipids in induced diabetic mice]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2018 Feb 8;34(2):130-133. doi: 10.12047/j.cjap.5547.2018.032. Chinese. PubMed PMID: 29926676. 4: Cardoso SH, de Oliveira CR, Guimarães AS, Nascimento J, de Oliveira Dos Santos Carmo J, de Souza Ferro JN, de Carvalho Correia AC, Barreto E. Synthesis of newly functionalized 1,4-naphthoquinone derivatives and their effects on wound healing in alloxan-induced diabetic mice. Chem Biol Interact. 2018 Jun 11;291:55-64. doi: 10.1016/j.cbi.2018.06.007. [Epub ahead of print] PubMed PMID: 29902415. 5: Zhang Q, Olatunji OJ, Chen H, Tola AJ, Oluwaniyi OO. Evaluation of the antidiabetic activity of polysaccharide from Cordyceps cicadae in experimental diabetic rats. Chem Biodivers. 2018 Jun 6. doi: 10.1002/cbdv.201800219. [Epub ahead of print] PubMed PMID: 29874416. 6: Vijayalakshmi K, Selvaraj CI. Evaluation of Antidiabetic Potential of Sarcostemma brevistigma Wight & Arn. Using Alloxan-Induced Diabetic Murine Model. Appl Biochem Biotechnol. 2018 Jun 6. doi: 10.1007/s12010-018-2798-z. [Epub ahead of print] PubMed PMID: 29872991. 7: Johar D, Maher A, Aboelmagd O, Hammad A, Morsi M, Warda HF, Awad HI, Mohamed TA, Zaky S. Whole-food phytochemicals antioxidative potential in alloxan-diabetic rats. Toxicol Rep. 2018 Jan 12;5:240-250. doi: 10.1016/j.toxrep.2018.01.002. eCollection 2018. PubMed PMID: 29854595; PubMed Central PMCID: PMC5977378. 8: Carvalho VF, Barreto EO, Arantes ACS, Serra MF, Ferreira TPT, Jannini-Sá YAP, Hogaboam CM, Martins MA, Silva PMR. Diabetes Downregulates Allergen-Induced Airway Inflammation in Mice. Mediators Inflamm. 2018 Apr 15;2018:6150843. doi: 10.1155/2018/6150843. eCollection 2018. PubMed PMID: 29849493; PubMed Central PMCID: PMC5925213. 9: Kura RR, Kilari EK, Shaik M. Influence of aprepitant on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits. PeerJ. 2018 May 22;6:e4798. doi: 10.7717/peerj.4798. eCollection 2018. PubMed PMID: 29844963; PubMed Central PMCID: PMC5969050. 10: Ru Y, Chen X, Xu J, Huang L, Jiang M, Guo L, Lin Z, Qiu B, Wong KY. Hypoglycemic effects of a polysaccharide from Tetrastigma hemsleyanum Diels et Gilg in alloxan-induced diabetic mice. Chem Biodivers. 2018 May 28. doi: 10.1002/cbdv.201800070. [Epub ahead of print] PubMed PMID: 29806965. 11: Marasco MR, Conteh AM, Reissaus CA, Cupit V JE, Appleman EM, Mirmira RG, Linnemann AK. Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response. Diabetes. 2018 May 21. pii: db171280. doi: 10.2337/db17-1280. [Epub ahead of print] PubMed PMID: 29784660. 12: Liu C, Liu R, Wu X, Tan P, Fu H, Wang X, Liu T, Li G. [Effects of peroxisome proliferator-activated receptor γ-toll-like receptor 4-tumor necrosis factor-α targeted pathway on hyperglycemia induced myocardium inflammation and oxidative stress]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018 May;30(5):416-421. doi: 10.3760/cma.j.issn.2095-4352.2018.05.005. Chinese. PubMed PMID: 29764544. 13: Ajiboye BO, Ojo OA, Akuboh OS, Abiola OM, Idowu O, Amuzat AO. Anti-Hyperglycemic and Anti-Inflammatory Activities of Polyphenolic-Rich Extract of Syzygium cumini Linn Leaves in Alloxan-Induced Diabetic Rats. J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18770630. doi: 10.1177/2515690X18770630. PubMed PMID: 29756477; PubMed Central PMCID: PMC5954443. 14: Ozaki K, Terayama Y, Matsuura T, Narama I. Effect of combined dyslipidemia and hyperglycemia on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats. J Toxicol Pathol. 2018 Apr;31(2):125-133. doi: 10.1293/tox.2017-0063. Epub 2018 Feb 12. PubMed PMID: 29750001; PubMed Central PMCID: PMC5938213. 15: Heneberg P. Redox Regulation of Hexokinases. Antioxid Redox Signal. 2018 Jun 18. doi: 10.1089/ars.2017.7255. [Epub ahead of print] PubMed PMID: 29742915. 16: Yang Y, Zhao J, Qiu J, Li J, Liang X, Zhang Z, Zhang X, Fu H, Korantzopoulos P, Letsas KP, Tse G, Li G, Liu T. Xanthine Oxidase Inhibitor Allopurinol Prevents Oxidative Stress-Mediated Atrial Remodeling in Alloxan-Induced Diabetes Mellitus Rabbits. J Am Heart Assoc. 2018 May 2;7(10). pii: e008807. doi: 10.1161/JAHA.118.008807. PubMed PMID: 29720500. 17: Yin P, Wang Y, Yang L, Sui J, Liu Y. Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract from Mongolian Oak Cups Enriched in Ellagic Acid, Kaempferol and Their Derivatives. Molecules. 2018 Apr 30;23(5). pii: E1046. doi: 10.3390/molecules23051046. PubMed PMID: 29710864. 18: Lohumi S, Lee H, Kim MS, Qin J, Kandpal LM, Bae H, Rahman A, Cho BK. Calibration and testing of a Raman hyperspectral imaging system to reveal powdered food adulteration. PLoS One. 2018 Apr 30;13(4):e0195253. doi: 10.1371/journal.pone.0195253. eCollection 2018. PubMed PMID: 29708973; PubMed Central PMCID: PMC5927415. 19: Jasso-Villagomez EI, Garcia-Lorenzana M, Almanza-Perez JC, Fortis-Barrera MA, Blancas-Flores G, Roman-Ramos R, Prado-Barragan LA, Alarcon-Aguilar FJ. Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPARγ expression. Braz J Med Biol Res. 2018;51(6):e7238. doi: 10.1590/1414-431x20187238. Epub 2018 Apr 19. PubMed PMID: 29694509; PubMed Central PMCID: PMC5996452. 20: Bae HD, Lee J, Jun KY, Kwon Y, Lee K. Modification of translationally controlled tumor protein-derived protein transduction domain for improved intranasal delivery of insulin. Drug Deliv. 2018 Nov;25(1):1025-1032. doi: 10.1080/10717544.2018.1464081. PubMed PMID: 29688087.

View History

Cetalkonium chloride

Cetalkonium chloride

Featured