Iduronate 2-sulfate | CAS#89846-17-3 | sulfatase enzyme

MedKoo Cat#: 597368 | Name: Iduronate 2-sulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iduronate 2-sulfate is a sulfatase enzyme associated with Hunter syndrome.

Chemical Structure

Iduronate 2-sulfate

CAS#89846-17-3

Theoretical Analysis

MedKoo Cat#: 597368

Name: Iduronate 2-sulfate

CAS#: 89846-17-3

Chemical Formula: C6H10O10S

Exact Mass: 273.9995

Molecular Weight: 274.19

Elemental Analysis: C, 26.28; H, 3.68; O, 58.35; S, 11.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Iduronate 2-sulfate;

IUPAC/Chemical Name

(2R,3S,4S,5R)-2,3,4-trihydroxy-6-oxo-5-(sulfooxy)hexanoic acid

InChi Key

PURMPUDWXOWORS-SKNVOMKLSA-N

InChi Code

InChI=1S/C6H10O10S/c7-1-2(16-17(13,14)15)3(8)4(9)5(10)6(11)12/h1-5,8-10H,(H,11,12)(H,13,14,15)/t2-,3+,4-,5+/m0/s1

SMILES Code

O[C@H]([C@@H](O)C(O)=O)[C@@H]([C@@H](OS(O)(=O)=O)C=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 274.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Alméciga-Díaz CJ, Tolosa-Díaz AD, Pimentel LN, Bonilla YA, Rodríguez-López A, Espejo-Mojica AJ, Patiño JD, Sánchez OF, Gonzalez-Santos J. Anaerobic sulfatase maturase AslB from Escherichia coli activates human recombinant iduronate-2-sulfate sulfatase (IDS) and N-acetylgalactosamine-6-sulfate sulfatase (GALNS). Gene. 2017 Nov 15;634:53-61. doi: 10.1016/j.gene.2017.08.043. Epub 2017 Sep 4. PubMed PMID: 28882567. 2: Chung JK, Brown E, Crooker B, Palmieri KJ, McCauley TG. Biodistribution of Idursulfase Formulated for Intrathecal Use (Idursulfase-IT) in Cynomolgus Monkeys after Intrathecal Lumbar Administration. PLoS One. 2016 Oct 20;11(10):e0164765. doi: 10.1371/journal.pone.0164765. eCollection 2016. PubMed PMID: 27764180; PubMed Central PMCID: PMC5072681. 3: Morales-Álvarez ED, Rivera-Hoyos CM, Landázuri P, Poutou-Piñales RA, Pedroza-Rodríguez AM. Bioinformatic Analysis of the Human Recombinant Iduronate 2-Sulfate Sulfatase. Open Microbiol J. 2016 May 31;10:124-32. doi: 10.2174/1874285801610010124. eCollection 2016. PubMed PMID: 27335624; PubMed Central PMCID: PMC4899537. 4: Prasad C, Rupar CA, Campbell C, Napier M, Ramsay D, Tay KY, Sharan S, Prasad AN. Case of multiple sulfatase deficiency and ocular albinism: a diagnostic odyssey. Can J Neurol Sci. 2014 Sep;41(5):626-31. doi: 10.1017/cjn.2014.12. PubMed PMID: 25373814. 5: Sista RS, Wang T, Wu N, Graham C, Eckhardt A, Winger T, Srinivasan V, Bali D, Millington DS, Pamula VK. Multiplex newborn screening for Pompe, Fabry, Hunter, Gaucher, and Hurler diseases using a digital microfluidic platform. Clin Chim Acta. 2013 Sep 23;424:12-8. doi: 10.1016/j.cca.2013.05.001. Epub 2013 May 7. PubMed PMID: 23660237; PubMed Central PMCID: PMC3926752. 6: Morales-Álvarez ED, Rivera-Hoyos CM, Baena-Moncada AM, Landázuri P, Poutou-Piñales RA, Sáenz-Suárez H, Barrera LA, Echeverri-Peña OY. Low-scale expression and purification of an active putative iduronate 2-sulfate sulfatase-Like enzyme from Escherichia coli K12. J Microbiol. 2013 Apr;51(2):213-21. doi: 10.1007/s12275-013-2416-2. Epub 2013 Apr 27. PubMed PMID: 23625223. 7: Sosa AC, Espejo AJ, Rodriguez EA, Lizaraso LM, Rojas A, Guevara J, Echeverri OY, Barrera LA. Development of a sandwich enzyme linked immunosorbent assay (ELISA) for the quantification of iduronate-2-sulfate sulfatase. J Immunol Methods. 2011 May 31;368(1-2):64-70. doi: 10.1016/j.jim.2011.03.004. Epub 2011 Apr 5. PubMed PMID: 21447345. 8: Wolfe BJ, Blanchard S, Sadilek M, Scott CR, Turecek F, Gelb MH. Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: application to screening newborns for mucopolysaccharidosis II (Hunter Syndrome). Anal Chem. 2011 Feb 1;83(3):1152-6. doi: 10.1021/ac102777s. Epub 2010 Dec 30. PubMed PMID: 21192662; PubMed Central PMCID: PMC3442111. 9: Capriotti E, Arbiza L, Casadio R, Dopazo J, Dopazo H, Marti-Renom MA. Use of estimated evolutionary strength at the codon level improves the prediction of disease-related protein mutations in humans. Hum Mutat. 2008 Jan;29(1):198-204. PubMed PMID: 17935148. 10: Sáenz H, Lareo L, Poutou RA, Sosa AC, Barrera LA. [Computational prediction of the tertiary structure of the human iduronate 2-sulfate sulfatase]. Biomedica. 2007 Mar;27(1):7-20. Epub 2007 May 31. Spanish. PubMed PMID: 17546220. 11: Kato T, Kato Z, Kuratsubo I, Ota T, Orii T, Kondo N, Suzuki Y. Evaluation of ADL in patients with Hunter disease using FIM score. Brain Dev. 2007 Jun;29(5):298-305. Epub 2007 Feb 20. PubMed PMID: 17307320. 12: Hricovíni M. B3LYP/6-311++G** study of structure and spin-spin coupling constant in methyl 2-O-sulfo-alpha-L-iduronate. Carbohydr Res. 2006 Nov 6;341(15):2575-80. Epub 2006 Aug 23. PubMed PMID: 16930570. 13: Lualdi S, Di Rocco M, Corsolini F, Spada M, Bembi B, Cotugno G, Battini R, Stroppiano M, Gabriela Pittis M, Filocamo M. Identification of nine new IDS alleles in mucopolysaccharidosis II. Quantitative evaluation by real-time RT-PCR of mRNAs sensitive to nonsense-mediated and nonstop decay mechanisms. Biochim Biophys Acta. 2006 Apr;1762(4):478-84. Epub 2006 Feb 9. PubMed PMID: 16495038. 14: Fuller M, Chau A, Nowak RC, Hopwood JJ, Meikle PJ. A defect in exodegradative pathways provides insight into endodegradation of heparan and dermatan sulfates. Glycobiology. 2006 Apr;16(4):318-25. Epub 2005 Dec 23. PubMed PMID: 16377754. 15: Bao X, Pavão MS, Dos Santos JC, Sugahara K. A functional dermatan sulfate epitope containing iduronate(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate) disaccharide in the mouse brain: demonstration using a novel monoclonal antibody raised against dermatan sulfate of ascidian Ascidia nigra. J Biol Chem. 2005 Jun 17;280(24):23184-93. Epub 2005 Apr 22. PubMed PMID: 15849184. 16: Lindahl B, Westling C, Giménez-Gallego G, Lindahl U, Salmivirta M. Common binding sites for beta-amyloid fibrils and fibroblast growth factor-2 in heparan sulfate from human cerebral cortex. J Biol Chem. 1999 Oct 22;274(43):30631-5. PubMed PMID: 10521448. 17: Aronovich EL, Pan D, Whitley CB. Molecular genetic defect underlying alpha-L-iduronidase pseudodeficiency. Am J Hum Genet. 1996 Jan;58(1):75-85. PubMed PMID: 8554071; PubMed Central PMCID: PMC1914939. 18: Timms KM, Lu F, Shen Y, Pierson CA, Muzny DM, Gu Y, Nelson DL, Gibbs RA. 130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. Genome Res. 1995 Aug;5(1):71-8. PubMed PMID: 8717057. 19: Daniele A, Di Natale P. Expression of the two iduronate-2-sulfatase cDNAs. Biochem Mol Biol Int. 1995 Jun;36(2):311-7. PubMed PMID: 7663435. 20: Nagasawa K, Uchiyama H, Sato N, Hatano A. Chemical change involved in the oxidative-reductive depolymerization of heparin. Carbohydr Res. 1992 Dec 15;236:165-80. PubMed PMID: 1337863.