Kinetensin Free Base | CAS# 103131-69-7 (free base) | nonapeptide

MedKoo Cat#: 414246 | Name: Kinetensin Free Base

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kinetensin Free Base is a nonapeptide with neurotensin-like immunoreactivity; isolated from pepsin-treated human plasma.

Chemical Structure

Kinetensin Free Base

CAS#103131-69-7 (free base)

Theoretical Analysis

MedKoo Cat#: 414246

Name: Kinetensin Free Base

CAS#: 103131-69-7 (free base)

Chemical Formula: C56H85N17O11

Exact Mass: 1171.6614

Molecular Weight: 1172.40

Elemental Analysis: C, 57.37; H, 7.31; N, 20.31; O, 15.01

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 380.00	2 Weeks
10mg	USD 690.00	2 Weeks

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Related CAS #

103131-69-7 (free base); Kinetensin TFA salt

Synonym

Kinetensin Free Base

IUPAC/Chemical Name

L-isoleucyl-L-alanyl-L-arginyl-L-arginyl-L-histidyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-leucine

InChi Key

PANUJGMSOSQAAY-IHXGQVBNSA-N

InChi Code

InChI=1S/C56H85N17O11/c1-6-32(4)45(57)52(81)66-33(5)46(75)67-38(15-10-22-63-55(58)59)47(76)68-39(16-11-23-64-56(60)61)48(77)71-42(28-36-29-62-30-65-36)53(82)73-24-12-17-44(73)51(80)70-41(27-35-18-20-37(74)21-19-35)49(78)69-40(26-34-13-8-7-9-14-34)50(79)72-43(54(83)84)25-31(2)3/h7-9,13-14,18-21,29-33,38-45,74H,6,10-12,15-17,22-28,57H2,1-5H3,(H,62,65)(H,66,81)(H,67,75)(H,68,76)(H,69,78)(H,70,80)(H,71,77)(H,72,79)(H,83,84)(H4,58,59,63)(H4,60,61,64)/t32-,33-,38-,39-,40-,41-,42-,43-,44-,45-/m0/s1

SMILES Code

CC[C@@H]([C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CC(C)C)=O)Cc2ccccc2)=O)Cc3ccc(O)cc3)=O)=O)Cc4[nH]cnc4)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)C)=O)N)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,172.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Read D, Shulkes A, Fletcher D, Hardy K. Pharmacokinetics and biological activity of kinetensin in conscious sheep. Agents Actions. 1993 Mar;38(3-4):231-9. doi: 10.1007/BF01976215. PMID: 8213349. 2: Sydbom A, Ware J, Mogard MH. Stimulation of histamine release by the peptide kinetensin. Agents Actions. 1989 Apr;27(1-2):68-71. doi: 10.1007/BF02222201. PMID: 2473637. 3: Mogard MH, Kobayashi R, Chen CF, Lee TD, Reeve JR Jr, Shively JE, Walsh JH. The amino acid sequence of kinetensin, a novel peptide isolated from pepsin- treated human plasma: homology with human serum albumin, neurotensin and angiotensin. Biochem Biophys Res Commun. 1986 May 14;136(3):983-8. doi: 10.1016/0006-291x(86)90429-8. PMID: 3087352. 4: Proniewicz E, Małuch I, Kudelski A, Prahl A. Adsorption of (Phe-h5)/(Phe-d5)-substituted peptides from neurotensin family on the nanostructured surfaces of Ag and Cu: SERS studies. Spectrochim Acta A Mol Biomol Spectrosc. 2020 Dec 5;242:118748. doi: 10.1016/j.saa.2020.118748. Epub 2020 Jul 21. PMID: 32721658. 5: Keegan KD, Woodruff GN, Pinnock RD. The pharmacology of neurotensin analogues on neurones in the rat substantia nigra, pars compacta in vitro. Eur J Pharmacol. 1994 Feb 21;253(1-2):131-7. doi: 10.1016/0014-2999(94)90767-6. PMID: 8013539. 6: Bunnett NW, Goldstein SM, Nakazato P. Isolation of a neuropeptide-degrading carboxypeptidase from the human stomach. Gastroenterology. 1992 Jan;102(1):76-87. doi: 10.1016/0016-5085(92)91786-4. PMID: 1309362. 7: Goldstein SM, Leong J, Bunnett NW. Human mast cell proteases hydrolyze neurotensin, kinetensin and Leu5-enkephalin. Peptides. 1991 Sep- Oct;12(5):995-1000. doi: 10.1016/0196-9781(91)90049-u. PMID: 1800960. 8: Clemens A, Katsoulis S, Nustede R, Seebeck J, Seyfarth K, Morys-Wortmann C, Feurle GE, Fölsch UR, Schmidt WE. Relaxant effect of xenin on rat ileum is mediated by apamin-sensitive neurotensin-type receptors. Am J Physiol. 1997 Jan;272(1 Pt 1):G190-6. doi: 10.1152/ajpgi.1997.272.1.G190. PMID: 9038893. 9: Lee J, Park H, Kwon H, Kwon G, Jeon A, Kim HI, Sung BJ, Moon B, Oh HB. One- step peptide backbone dissociations in negative-ion free radical initiated peptide sequencing mass spectrometry. Anal Chem. 2013 Aug 6;85(15):7044-51. doi: 10.1021/ac303517h. Epub 2013 Jul 10. PMID: 23802150. 10: Mogard MH, Kobayashi R, Lee TD, Chen CF, Hagiwara M, Leung F, Reeve JR Jr, Shively JE, Walsh JH. Neurotensin-like immunoreactivity generated by pepsin from human plasma and gastric tissue. Regul Pept. 1987 Aug 17;18(3-4):221-32. doi: 10.1016/0167-0115(87)90010-3. PMID: 3118424.