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MedKoo Cat#: 563107 | Name: IMC-48

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IMC-48 is a BCL2 i-motif-interactive compound that acts by stabilizing or facilitating the folding of the i-motif.

Chemical Structure

IMC-48
IMC-48
CAS#106068-99-9 (iodide)

Theoretical Analysis

MedKoo Cat#: 563107

Name: IMC-48

CAS#: 106068-99-9 (iodide)

Chemical Formula: C35H63IN2O

Exact Mass: 654.3985

Molecular Weight: 654.80

Elemental Analysis: C, 64.20; H, 9.70; I, 19.38; N, 4.28; O, 2.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
805222-83-7 (cation) 106068-99-9 (iodide)
Synonym
IMC-48; IMC 48; IMC48; NSC-138948; NSC 138948; NSC138948;
IUPAC/Chemical Name
1-(2-(((3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-((R)-6-methylheptan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)amino)-2-oxoethyl)-1-methylpiperidin-1-ium iodide
InChi Key
OUJMHBPBYIMSPJ-LIDSYRIPSA-N
InChi Code
InChI=1S/C35H62N2O.HI/c1-25(2)11-10-12-26(3)30-15-16-31-29-14-13-27-23-28(36-33(38)24-37(6)21-8-7-9-22-37)17-19-34(27,4)32(29)18-20-35(30,31)5;/h25-32H,7-24H2,1-6H3;1H/t26-,27+,28-,29+,30-,31+,32+,34+,35-;/m1./s1
SMILES Code
C[N+]1(CC(N[C@@H]2CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@@]5([H])[C@]4([H])CC[C@@]3([H])C2)=O)CCCCC1.[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 654.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fernandez M, Toimil RF, Rasslan Z, Ilias EJ, Gradinar AL, Malheiros CA. ASSESSMENT OF BODY FAT IN OBESE PATIENTS PREOPERATIVELY FOR BARIATRIC SURGERY. Arq Bras Cir Dig. 2016;29Suppl 1(Suppl 1):59-61. doi: 10.1590/0102-6720201600S10015. English, Portuguese. PubMed PMID: 27683778; PubMed Central PMCID: PMC5064249. 2: Cui Y, Koirala D, Kang H, Dhakal S, Yangyuoru P, Hurley LH, Mao H. Molecular population dynamics of DNA structures in a bcl-2 promoter sequence is regulated by small molecules and the transcription factor hnRNP LL. Nucleic Acids Res. 2014 May;42(9):5755-64. doi: 10.1093/nar/gku185. Epub 2014 Mar 7. PubMed PMID: 24609386; PubMed Central PMCID: PMC4027204. 3: Kang HJ, Kendrick S, Hecht SM, Hurley LH. The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules. J Am Chem Soc. 2014 Mar 19;136(11):4172-85. doi: 10.1021/ja4109352. Epub 2014 Mar 7. PubMed PMID: 24559432; PubMed Central PMCID: PMC3985447.