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MedKoo Cat#: 525339 | Name: HIE-124

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HIE-124 is a CNS active anticonvulsant and ultra-short acting hypnotic.

Chemical Structure

HIE-124
HIE-124
CAS#805326-00-5

Theoretical Analysis

MedKoo Cat#: 525339

Name: HIE-124

CAS#: 805326-00-5

Chemical Formula: C10H12N2O3S

Exact Mass: 240.0569

Molecular Weight: 240.28

Elemental Analysis: C, 49.99; H, 5.03; N, 11.66; O, 19.98; S, 13.34

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
HIE-124
IUPAC/Chemical Name
Ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate
InChi Key
UXGPDPNGDCOQBY-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H12N2O3S/c1-2-15-9(14)7-6-16-10-11-8(13)4-3-5-12(7)10/h6H,2-5H2,1H3
SMILES Code
O=C(C1=CSC(N1CCC2)=NC2=O)OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 240.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: El-Subbagh HI, El-Azab AS, Hassan GS, El-Messery SM, Abdel-Aziz AA, El-Taher KE. Thiadiazolodiazepine analogues as a new class of neuromuscular blocking agents: Synthesis, biological evaluation and molecular modeling study. Eur J Med Chem. 2017 Jan 27;126:15-23. doi: 10.1016/j.ejmech.2016.09.096. Epub 2016 Sep 30. PubMed PMID: 27744183. 2: El-Subbagh HI, Hassan GS, El-Taher KE, El-Messery SM, Al-Azab AS, Abdelaziz AA, Hefnawy MM. Synthesis, biological evaluation and molecular modeling study of thiadiazolo[3,2-a][1,3]diazepine analogues of HIE-124 as a new class of short acting hypnotics. Eur J Med Chem. 2016 Nov 29;124:237-247. doi: 10.1016/j.ejmech.2016.08.038. Epub 2016 Aug 22. PubMed PMID: 27597405. 3: Al-Rashood ST, Hassan GS, El-Messery SM, El-Taher KE, Hefnawy MM, Al-Omar MA, El-Subbagh HI. Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents. Bioorg Med Chem Lett. 2016 Jan 15;26(2):445-53. doi: 10.1016/j.bmcl.2015.11.097. Epub 2015 Dec 7. PubMed PMID: 26706170. 4: Kadi A, Hefnawy M, Al-Majed A, Alonezi S, Asiri Y, Attia S, Abourashed E, El-Subbagh H. Liquid chromatographic high-throughput analysis of the new ultra-short acting hypnotic 'HIE-124' and its metabolite in mice serum using a monolithic silica column. Analyst. 2011 Feb 7;136(3):591-7. doi: 10.1039/c0an00381f. Epub 2010 Nov 16. PubMed PMID: 21079880. 5: Hefnawy M, Al-Omar M, Julkhuf S, Attia S, Abourashed E, El-Subbagh H. Novel, selective sample stacking microemulsion electrokinetic capillary chromatography induced by reverse migrating pseudostationary phase for the determination of the new ultra-short acting hypnotic "HIE-124" in mice serum. Anal Chim Acta. 2010 Jul 19;673(2):194-9. doi: 10.1016/j.aca.2010.05.030. Epub 2010 May 27. PubMed PMID: 20599035. 6: Kadi AA, El-Kashef HA, Abdel-Aziz AA, Hassan GS, Tettey J, Grant MH, Lehmann J, El-Subbagh HI. Synthesis, ultra-short acting hypnotic activity, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a] [1,3]diazepin-3-carboxylate (HIE-124). Arch Pharm (Weinheim). 2008 Feb;341(2):81-9. doi: 10.1002/ardp.200700132. PubMed PMID: 18214840. 7: El-Subbagh HI, El-Kashef HA, Kadi AA, Abdel-Aziz AA, Hassan GS, Tettey J, Lehmann J. New ultra-short acting hypnotic: synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124). Bioorg Med Chem Lett. 2008 Jan 1;18(1):72-7. Epub 2007 Nov 7. PubMed PMID: 18023180.