Valpromide | CAS#2430-27-5 | antiepileptic

MedKoo Cat#: 584466 | Name: Valpromide

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Valpromide is an antiepileptic drug, derivative of Valproic acid (VPA), used as a mood-stabilizer in bipolar disorder.

Chemical Structure

Valpromide

CAS#2430-27-5

Theoretical Analysis

MedKoo Cat#: 584466

Name: Valpromide

CAS#: 2430-27-5

Chemical Formula: C8H17NO

Exact Mass: 143.1310

Molecular Weight: 143.23

Elemental Analysis: C, 67.09; H, 11.96; N, 9.78; O, 11.17

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 280.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Valpromide; Depamide

IUPAC/Chemical Name

2-propylpentanamide

InChi Key

OMOMUFTZPTXCHP-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H17NO/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H2,9,10)

SMILES Code

CCCC(CCC)C(N)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 143.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: M H Subari IAA, Mutthumanickam G, Hj Jikal M, Shah MD, Tan JK, Tan YS, Palasubermaniam P, Palaniveloo K, Sathiya Seelan JS. LC-MS/MS profiling of the poisonous wild mushroom, Entoloma mastoideum, (Entolomataceae, Basidiomycota) in Sabah (Northern Borneo), Malaysia. Toxicon. 2024 Nov 28;251:108133. doi: 10.1016/j.toxicon.2024.108133. Epub 2024 Oct 18. PMID: 39426425. 2: Gorres KL, Reineke DM, Miller G. Transcriptome analysis of Burkitt lymphoma cells treated with anti-convulsant drugs that are inhibitors of Epstein-Barr virus lytic reactivation. PLoS One. 2024 Apr 18;19(4):e0299198. doi: 10.1371/journal.pone.0299198. PMID: 38635661; PMCID: PMC11025866. 3: Delage C, Palayer M, Etain B, Hagenimana M, Blaise N, Smati J, Chouchana M, Bloch V, Besson VC. Corrigendum to "Valproate, divalproex, valpromide: Are the differences in indications justified?" [Biomed. Pharmacother., 158 (2023) 114051]. Biomed Pharmacother. 2023 Dec;168:115705. doi: 10.1016/j.biopha.2023.115705. Epub 2023 Oct 13. Erratum for: Biomed Pharmacother. 2023 Feb;158:114051. doi: 10.1016/j.biopha.2022.114051. PMID: 37838533. 4: Aly SM, Gish A, Hakim F, Guelmi D, Mesli V, Hédouin V, Allorge D, Gaulier JM. In the case of extensively putrefied bodies, the analysis of entomological samples may support and complement the toxicological results obtained with other alternative matrices. Leg Med (Tokyo). 2023 Jul;63:102261. doi: 10.1016/j.legalmed.2023.102261. Epub 2023 Apr 17. PMID: 37087785. 5: Delage C, Palayer M, Etain B, Hagenimana M, Blaise N, Smati J, Chouchana M, Bloch V, Besson VC. Valproate, divalproex, valpromide: Are the differences in indications justified? Biomed Pharmacother. 2023 Feb;158:114051. doi: 10.1016/j.biopha.2022.114051. Epub 2022 Dec 13. Erratum in: Biomed Pharmacother. 2023 Dec;168:115705. doi: 10.1016/j.biopha.2023.115705. PMID: 36521249. 6: Lee H, Hwang YJ, Park JH, Cho DH. Valproic acid decreases vascular smooth muscle cell proliferation via protein phosphatase 2A-mediated p70 S6 kinase inhibition. Biochem Biophys Res Commun. 2022 May 28;606:94-99. doi: 10.1016/j.bbrc.2022.03.100. Epub 2022 Mar 22. PMID: 35339758. 7: Andreu S, Ripa I, Praena B, López-Guerrero JA, Bello-Morales R. The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines. Viruses. 2021 Dec 15;13(12):2522. doi: 10.3390/v13122522. PMID: 34960791; PMCID: PMC8708079. 8: Tarasenko N, Wilner HJ, Nudelman A, Kessler-Icekson G, Rephaeli A. Valproic Acid Prodrug Affects Selective Markers, Augments Doxorubicin Anticancer Activity and Attenuates Its Toxicity in a Murine Model of Aggressive Breast Cancer. Pharmaceuticals (Basel). 2021 Nov 30;14(12):1244. doi: 10.3390/ph14121244. PMID: 34959644; PMCID: PMC8706415. 9: Sinha P, Cree SL, Miller AL, Pearson JF, Kennedy MA. Transcriptional analysis of sodium valproate in a serotonergic cell line reveals gene regulation through both HDAC inhibition-dependent and independent mechanisms. Pharmacogenomics J. 2021 Jun;21(3):359-375. doi: 10.1038/s41397-021-00215-x. Epub 2021 Mar 1. PMID: 33649518. 10: Liu P, Wang T, Yang R, Dong W, Wang Q, Guo Z, Ma C, Wang W, Li H, Su X. Preclinical Evaluation of a Novel 99mTc-Labeled CB86 for Rheumatoid Arthritis Imaging. ACS Omega. 2020 Nov 30;5(49):31657-31664. doi: 10.1021/acsomega.0c04066. PMID: 33344817; PMCID: PMC7745438. 11: Boels D, Mégarbane B, Bouquié R. Delayed and prolonged coma following valpromide poisoning in a 4-year-old girl. Clin Toxicol (Phila). 2021 Aug;59(8):763-764. doi: 10.1080/15563650.2020.1853144. Epub 2020 Dec 4. PMID: 33274655. 12: Andreu S, Ripa I, Bello-Morales R, López-Guerrero JA. Valproic Acid and Its Amidic Derivatives as New Antivirals against Alphaherpesviruses. Viruses. 2020 Nov 26;12(12):1356. doi: 10.3390/v12121356. PMID: 33256172; PMCID: PMC7760627. 13: Jouvent E, Alili N, Hervé D, Chabriat H. Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms. J Alzheimers Dis. 2020;78(3):907-910. doi: 10.3233/JAD-201086. PMID: 33074242. 14: Kim K, Kim H, Bae SH, Lee SY, Kim YH, Na J, Lee CH, Lee MS, Ko GB, Kim KY, Lee SH, Song IH, Cheon GJ, Kang KW, Kim SE, Chung JK, Kim EE, Paek SH, Lee JS, Lee BC, Youn H. [18F]CB251 PET/MR imaging probe targeting translocator protein (TSPO) independent of its Polymorphism in a Neuroinflammation Model. Theranostics. 2020 Jul 23;10(20):9315-9331. doi: 10.7150/thno.46875. PMID: 32802194; PMCID: PMC7415805. 15: Musatadi M, González-Gaya B, Irazola M, Prieto A, Etxebarria N, Olivares M, Zuloaga O. Focused ultrasound-based extraction for target analysis and suspect screening of organic xenobiotics in fish muscle. Sci Total Environ. 2020 Oct 20;740:139894. doi: 10.1016/j.scitotenv.2020.139894. Epub 2020 Jun 4. PMID: 32562984. 16: Chu Z, Liu P, Li X, Liu Y, Liu F, Lei G, Yang L, Deng L, Dang Y. Microinjection of valproic acid into the ventrolateral orbital cortex exerts an antinociceptive effect in a rat of neuropathic pain. Psychopharmacology (Berl). 2020 Aug;237(8):2509-2516. doi: 10.1007/s00213-020-05551-7. Epub 2020 May 28. PMID: 32468099. 17: Cikánková T, Fišar Z, Hroudová J. In vitro effects of antidepressants and mood-stabilizing drugs on cell energy metabolism. Naunyn Schmiedebergs Arch Pharmacol. 2020 May;393(5):797-811. doi: 10.1007/s00210-019-01791-3. Epub 2019 Dec 19. PMID: 31858154. 18: Dedoni S, Marras L, Olianas MC, Ingianni A, Onali P. Downregulation of TrkB Expression and Signaling by Valproic Acid and Other Histone Deacetylase Inhibitors. J Pharmacol Exp Ther. 2019 Sep;370(3):490-503. doi: 10.1124/jpet.119.258129. Epub 2019 Jul 15. PMID: 31308194. 19: Tournier M, Neumann A, Pambrun E, Weill A, Chaffiol JP, Alla F, Bégaud B, Maura G, Verdoux H. Conventional mood stabilizers and/or second-generation antipsychotic drugs in bipolar disorders: A population-based comparison of risk of treatment failure. J Affect Disord. 2019 Oct 1;257:412-420. doi: 10.1016/j.jad.2019.07.054. Epub 2019 Jul 6. PMID: 31306992. 20: Praena B, Bello-Morales R, de Castro F, López-Guerrero JA. Amidic derivatives of valproic acid, valpromide and valnoctamide, inhibit HSV-1 infection in oligodendrocytes. Antiviral Res. 2019 Aug;168:91-99. doi: 10.1016/j.antiviral.2019.05.006. Epub 2019 May 25. PMID: 31132386.