MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 526083 | Name: Ralitoline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ralitoline is an anticonvulsant. Ralitoline has sodium channel blocking activities. The efficacy of this compound seems to be comparable or even better than that of conventional antiepileptics.

Chemical Structure

Ralitoline
Ralitoline
CAS#93738-40-0

Theoretical Analysis

MedKoo Cat#: 526083

Name: Ralitoline

CAS#: 93738-40-0

Chemical Formula: C13H13ClN2O2S

Exact Mass: 296.0386

Molecular Weight: 296.77

Elemental Analysis: C, 52.61; H, 4.42; Cl, 11.95; N, 9.44; O, 10.78; S, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Ralitoline; GOE-4942; PD-117818; Ralitolina; CI-946; Ralitolinum.
IUPAC/Chemical Name
(Z)-N-(2-Chloro-6-methylphenyl)-(3-methyl-4-oxothiazolidine-2-ylidene)acetamide
InChi Key
YJXQTIXFPYPQFT-SDQBBNPISA-N
InChi Code
InChI=1S/C13H13ClN2O2S/c1-8-4-3-5-9(14)13(8)15-10(17)6-12-16(2)11(18)7-19-12/h3-6H,7H2,1-2H3,(H,15,17)/b12-6-
SMILES Code
O=C(NC1=C(C)C=CC=C1Cl)/C=C(N2C)\SCC2=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dostal LA, Anderson JA. Developmental toxicity study in rats treated with the anticonvulsant, ralitoline. Teratology. 1995 Jan;51(1):11-9. PubMed PMID: 7597653. 2: Fischer W, Bodewei R, Satzinger G. Anticonvulsant and sodium channel blocking effects of ralitoline in different screening models. Naunyn Schmiedebergs Arch Pharmacol. 1992 Oct;346(4):442-52. PubMed PMID: 1331817. 3: Löscher W, von Hodenberg A, Nolting B, Fassbender CP, Taylor C. Ralitoline: a reevaluation of anticonvulsant profile and determination of "active" plasma concentrations in comparison with prototype antiepileptic drugs in mice. Epilepsia. 1991 Jul-Aug;32(4):560-8. PubMed PMID: 1868813. 4: Rock DM, McLean MJ, Macdonald RL, Catterall WA, Taylor CP. Ralitoline (CI-946) and CI-953 block sustained repetitive sodium action potentials in cultured mouse spinal cord neurons and displace batrachotoxinin A 20-alpha-benzoate binding in vitro. Epilepsy Res. 1991 Apr;8(3):197-203. PubMed PMID: 1651226. 5: Anhut H, Satzinger G, von Hodenberg A. Ralitoline. Epilepsy Res Suppl. 1991;3:141-5. Review. PubMed PMID: 1777070. 6: Wagner B, Strumpf G, Bartoszyk GD. Similar effects of ralitoline and phenytoin on papillary muscle action potentials: evidence for sodium antagonistic activity. Pharmacol Res Commun. 1987 Sep;19(9):591-6. PubMed PMID: 3432324.