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MedKoo Cat#: 558173 | Name: PD 124895

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PD 124895 is isolated from the fermentation broth of Streptomyces sp. No. 81-484 and the structure was established mainly on the basis of its physico-chemical properties. It is an antitumor antibiotic.

Chemical Structure

PD 124895
PD 124895
CAS#107140-30-7

Theoretical Analysis

MedKoo Cat#: 558173

Name: PD 124895

CAS#: 107140-30-7

Chemical Formula: C32H46O7

Exact Mass: 542.3200

Molecular Weight: 542.71

Elemental Analysis: C, 70.82; H, 8.54; O, 20.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PD 124895; PD-124895; PD124895; Kazusamycin B;
IUPAC/Chemical Name
2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-6-hydroxy-9-(hydroxymethyl)-3,5,7,11,15,17-hexamethyl-8-oxo-
InChi Key
OOQHBJFDAPXZJM-VYRSPHQHSA-N
InChi Code
InChI=1S/C32H46O7/c1-20(15-22(3)11-13-28-24(5)12-14-30(36)39-28)9-8-10-21(2)17-27(19-33)32(38)26(7)31(37)25(6)16-23(4)18-29(34)35/h8,10-15,17-18,20,24-28,31,33,37H,9,16,19H2,1-7H3,(H,34,35)/b10-8+,13-11+,21-17+,22-15+,23-18+
SMILES Code
O=C(O)/C=C(C)/CC(C)C(O)C(C)C(C(CO)/C=C(C)/C=C/CC(C)/C=C(C)/C=C/C1C(C)C=CC(O1)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 542.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hurley TR, Bunge RH, Willmer NE, Hokanson GC, French JC. PD 124,895 and PD 124,966, two new antitumor antibiotics. J Antibiot (Tokyo). 1986 Dec;39(12):1651-6. PubMed PMID: 3818438. 2: Funaishi K, Kawamura K, Sugiura Y, Nakahori N, Yoshida E, Okanishi M, Umezawa I, Funayama S, Komiyama K. Kazusamycin B, a novel antitumor antibiotic. J Antibiot (Tokyo). 1987 Jun;40(6):778-85. PubMed PMID: 3610834. 3: Umezawa I, Komiyama K. [Studies on the new antibiotic kazusamycin and related substances]. Gan To Kagaku Ryoho. 1987 Mar;14(3 Pt 2):858-64. Japanese. PubMed PMID: 3105461. 4: Takamiya K, Yoshida E, Takahashi T, Okura A, Okanishi M, Komiyama K, Umezawa I. The effect of kazusamycin B on the cell cycle and morphology of cultured L1210 cells. J Antibiot (Tokyo). 1988 Dec;41(12):1854-61. PubMed PMID: 3209477. 5: Yoshida E, Komiyama K, Naito K, Watanabe Y, Takamiya K, Okura A, Funaishi K, Kawamura K, Funayama S, Umezawa I. Antitumor effect of kazusamycin B on experimental tumors. J Antibiot (Tokyo). 1987 Nov;40(11):1596-604. PubMed PMID: 3693127.