NIC | CAS#114773-20-5 | host invasion inhibitor

MedKoo Cat#: 563008 | Name: NIC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NIC is an inhibitor of host invasion. It acts by targeting malaria merozoite surface protein-1 (MSP-1). It is also an inhibitor of VEGF binding to immobilized heparin.

Chemical Structure

NIC

CAS#114773-20-5

Theoretical Analysis

MedKoo Cat#: 563008

Name: NIC

CAS#: 114773-20-5

Chemical Formula: C15H16ClN3O3

Exact Mass: 321.0880

Molecular Weight: 321.76

Elemental Analysis: C, 55.99; H, 5.01; Cl, 11.02; N, 13.06; O, 14.92

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NIC;

IUPAC/Chemical Name

2-Butyl-5-chloro-3-(4-nitro-benzyl)-3H-imidazole-4-carbaldehyde

InChi Key

MXOCRZVWJNLURA-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H16ClN3O3/c1-2-3-4-14-17-15(16)13(10-20)18(14)9-11-5-7-12(8-6-11)19(21)22/h5-8,10H,2-4,9H2,1H3

SMILES Code

O=CC1=C(Cl)N=C(CCCC)N1CC2=CC=C([N+]([O-])=O)C=C2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 321.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Liu X, Lu L, Liu X, Pan C, Feng E, Wang D, Zhu L, Wang H. Comparative proteomics of Shigella flexneri 2a strain 301 using a rabbit ileal loop model reveals key proteins for bacterial adaptation in host niches. Int J Infect Dis. 2015 Nov;40:28-33. doi: 10.1016/j.ijid.2015.09.014. Epub 2015 Sep 28. PubMed PMID: 26417879. 2: Yang G, Wang L, Wang Y, Li P, Zhu J, Qiu S, Hao R, Wu Z, Li W, Song H. hfq regulates acid tolerance and virulence by responding to acid stress in Shigella flexneri. Res Microbiol. 2015 Jul-Aug;166(6):476-85. doi: 10.1016/j.resmic.2015.06.007. Epub 2015 Jun 24. PubMed PMID: 26117597. 3: Chandramohanadas R, Basappa, Russell B, Liew K, Yau YH, Chong A, Liu M, Gunalan K, Raman R, Renia L, Nosten F, Shochat SG, Dao M, Sasisekharan R, Suresh S, Preiser P. Small molecule targeting malaria merozoite surface protein-1 (MSP-1) prevents host invasion of divergent plasmodial species. J Infect Dis. 2014 Nov 15;210(10):1616-26. doi: 10.1093/infdis/jiu296. Epub 2014 May 26. PubMed PMID: 24864124; PubMed Central PMCID: PMC4334792. 4: Sheokand S, Brewin NJ. Cysteine proteases in nodulation and nitrogen fixation. Indian J Exp Biol. 2003 Oct;41(10):1124-32. Review. PubMed PMID: 15242278.