NIBR3049 | TCS-21311 | CAS#1260181-14-3 | JAK3 inhibitor

MedKoo Cat#: 206831 | Name: NIBR3049

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NIBR3049, also known as TCS-21311, is a potent and selective JAK3 inhibitor IC50 values of 8 nM..

Chemical Structure

NIBR3049

CAS#1260181-14-3

Theoretical Analysis

MedKoo Cat#: 206831

Name: NIBR3049

CAS#: 1260181-14-3

Chemical Formula: C27H25F3N4O4

Exact Mass: 526.1828

Molecular Weight: 526.52

Elemental Analysis: C, 61.59; H, 4.79; F, 10.82; N, 10.64; O, 12.15

Price and Availability

Size	Price	Availability
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks
25mg	USD 1,150.00	2 Weeks

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Related CAS #

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Synonym

NIBR3049; NIBR-3049; NIBR 3049; TCS-21311; TCS 21311; TCS21311.

IUPAC/Chemical Name

3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

InChi Key

CLGRAWDGLMENOD-UHFFFAOYSA-N

InChi Code

InChI=1S/C27H25F3N4O4/c1-26(2,38)25(37)34-11-9-33(10-12-34)15-7-8-19(27(28,29)30)17(13-15)21-22(24(36)32-23(21)35)18-14-31-20-6-4-3-5-16(18)20/h3-8,13-14,31,38H,9-12H2,1-2H3,(H,32,35,36)

SMILES Code

O=C(C(C1=CC(N2CCN(C(C(C)(O)C)=O)CC2)=CC=C1C(F)(F)F)=C3C4=CNC5=C4C=CC=C5)NC3=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM.

In vitro activity:

Here, by performing chemical screening for BMP substitutes, this study identified a small molecule, TCS21311, that can replace BMP7 and revealed a novel inhibitory role of BMP7 in JAK3-STAT3 signaling in NPC expansion culture. Further, this study found that TCS21311 facilitates the proliferation of mouse embryonic NPCs and human induced pluripotent stem cell-derived NPCs when added to the expansion culture. Reference: Biochem Biophys Res Commun. 2021 Jun 18;558:231-238. https://pubmed.ncbi.nlm.nih.gov/32113685/

In vivo activity:

TBD

	Solvent	mg/mL	mM	comments
Solubility
	DMSO	67.6	128.30

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 526.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Tsujimoto H, Araoka T, Nishi Y, Ohta A, Nakahata T, Osafune K. Small molecule TCS21311 can replace BMP7 and facilitate cell proliferation in in vitro expansion culture of nephron progenitor cells. Biochem Biophys Res Commun. 2021 Jun 18;558:231-238. doi: 10.1016/j.bbrc.2020.02.130. Epub 2020 Feb 26. PMID: 32113685.

In vitro protocol:

In vivo protocol:

TBD