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MedKoo Cat#: 573517 | Name: AK-135

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AK-135 is a derivative of 1,4-naphthoquinone (Menadione). AK-135 has been shown to restore the electron flow in defective respiratory chain (hypoxia or rotenone) systems more effectively than Menadione.

Chemical Structure

AK-135
AK-135
CAS#75397-64-7

Theoretical Analysis

MedKoo Cat#: 573517

Name: AK-135

CAS#: 75397-64-7

Chemical Formula: C17H20ClNO2

Exact Mass: 305.1183

Molecular Weight: 305.80

Elemental Analysis: C, 66.77; H, 6.59; Cl, 11.59; N, 4.58; O, 10.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AK 135, AK-135, AK135
IUPAC/Chemical Name
2-Methyl-3-(1-piperidinylmethyl)-1,4-naphthalenedione hydrochloride
InChi Key
XSNCPTIVNGCGBK-UHFFFAOYSA-N
InChi Code
1S/C17H19NO2.ClH/c1-12-15(11-18-9-5-2-6-10-18)17(20)14-8-4-3-7-13(14)16(12)19;/h3-4,7-8H,2,5-6,9-11H2,1H3;1H
SMILES Code
CC1=C(C(=O)c2ccccc2C1=O)CN3CCCCC3.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 305.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shneyvays V, Leshem D, Shmist Y, Zinman T, Shainberg A. Effects of menadione and its derivative on cultured cardiomyocytes with mitochondrial disorders. J Mol Cell Cardiol. 2005 Jul;39(1):149-58. PubMed PMID: 15893762. 2: Levin GS, Tremasova GIa, Kostova SV, Dregeris IaIa. [The mechanism of action of a synthetic derivative of 1,4-naphthoquinone on the respiratory chain of liver and heart mitochondria]. Biokhimiia. 1989 Oct;54(10):1630-7. Russian. PubMed PMID: 2574998.