L-Citronellol | CAS#7540-51-4 | fragrance

MedKoo Cat#: 596965 | Name: L-Citronellol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

L-Citronellol is a fragrance.

Chemical Structure

L-Citronellol

CAS#7540-51-4

Theoretical Analysis

MedKoo Cat#: 596965

Name: L-Citronellol

CAS#: 7540-51-4

Chemical Formula: C10H20O

Exact Mass: 156.1514

Molecular Weight: 156.27

Elemental Analysis: C, 76.86; H, 12.90; O, 10.24

Price and Availability

Size	Price	Availability	Quantity
5g	USD 250.00	2 Weeks
25g	USD 550.00	2 Weeks

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Synonym

L-Citronellol; (S)-(-)-Citronellol; beta-Citronellol; AI3-09552; AI3 09552; AI309552; FEMA No. 2309; β-Rhodinol; (-)-β-Citronellol;

IUPAC/Chemical Name

(S)-3,7-Dimethyl-6-octen-1-ol

InChi Key

QMVPMAAFGQKVCJ-JTQLQIEISA-N

InChi Code

InChI=1S/C10H20O/c1-9(2)5-4-6-10(3)7-8-11/h5,10-11H,4,6-8H2,1-3H3/t10-/m0/s1

SMILES Code

C/C(C)=C\CC[C@H](C)CCO

Appearance

Liquid

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

L-Citronellol is a fragrance.

In vitro activity:

The results found that citronellol treatment effectively hindered the cell death caused by 6-OHDA and thereby maintaining the cell viability in SH-SY5Y cells at 50 µg/mL concentration. Furthermore, citronellol hampered the 6-OHDA-induced apoptosis via the suppression of Bcl-2/Bax pathway. The western blotting results hypothesized that citronellol rescued SH-SY5Y cells from 6-OHDA-induced neurotoxicity via modulating ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Reference: Neurotox Res. 2022 Dec;40(6):2221-2237. https://pubmed.ncbi.nlm.nih.gov/36097250/

In vivo activity:

The present study investigated the neuroprotective mechanisms of citronellol against rotenone induced neurodegeneration by using rat model of Parkinson's disease (PD). Citronellol attenuated rotenone induced expression of pro-apoptotic protein Bax, reduced α-synuclein expression and enhanced Bcl-2 and mTOR levels. In addition, citronellol modulated autophagy pathway by decreasing LC-3 (Microtubule-associated proteins) and p62 levels. Reference: Heliyon. 2022 Nov 3;8(11):e11434. https://pubmed.ncbi.nlm.nih.gov/36387498/

Preparing Stock Solutions

The following data is based on the product molecular weight 156.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Shao J, Liu X, Lian M, Mao Y. Citronellol Prevents 6-OHDA-Induced Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Parkinson Disease Model of SH-SY5Y Cells via Modulating ROS-NO, MAPK/ERK, and PI3K/Akt Signaling Pathways. Neurotox Res. 2022 Dec;40(6):2221-2237. doi: 10.1007/s12640-022-00558-8. Epub 2022 Sep 12. PMID: 36097250. 2. Rajendran J, Pachaiappan P, Thangarasu R. Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells. Nutr Cancer. 2021;73(8):1448-1458. doi: 10.1080/01635581.2020.1800766. Epub 2020 Aug 10. PMID: 32772589. 3. Jayaraj RL, Azimullah S, Parekh KA, Ojha SK, Beiram R. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434. doi: 10.1016/j.heliyon.2022.e11434. PMID: 36387498; PMCID: PMC9663872. 4. Liu X, Zhu C, Yin Y. Anti-ischemic effect of monoterpene citronellol on experimental stroke models mediated by proinflammatroy cytokines. Comb Chem High Throughput Screen. 2022 Nov 10. doi: 10.2174/1386207326666221110092715. Epub ahead of print. PMID: 36372917.

In vitro protocol:

In vivo protocol:

1. Jayaraj RL, Azimullah S, Parekh KA, Ojha SK, Beiram R. Effect of citronellol on oxidative stress, neuroinflammation and autophagy pathways in an in vivo model of Parkinson's disease. Heliyon. 2022 Nov 3;8(11):e11434. doi: 10.1016/j.heliyon.2022.e11434. PMID: 36387498; PMCID: PMC9663872. 2. Liu X, Zhu C, Yin Y. Anti-ischemic effect of monoterpene citronellol on experimental stroke models mediated by proinflammatroy cytokines. Comb Chem High Throughput Screen. 2022 Nov 10. doi: 10.2174/1386207326666221110092715. Epub ahead of print. PMID: 36372917.

1: Lapczynski A, Bhatia SP, Letizia CS, Api AM. Fragrance material review on l-citronellol. Food Chem Toxicol. 2008 Nov;46 Suppl 11:S110-3. doi: 10.1016/j.fct.2008.06.056. Epub 2008 Jul 2. Review. PubMed PMID: 18640228. 2: Larsen W, Nakayama H, Fischer T, Elsner P, Frosch P, Burrows D, Jordan W, Shaw S, Wilkinson J, Marks J Jr, Sugawara M, Nethercott M, Nethercott J. Fragrance contact dermatitis: a worldwide multicenter investigation (Part II). Contact Dermatitis. 2001 Jun;44(6):344-6. PubMed PMID: 11380544.