FR171456 | CAS#168986-58-1 | NSDHL inhibitor| MedKoo

MedKoo Cat#: 565484 | Name: FR171456

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR171456 is a natural specific inhibitor of mammalian nsdhl and yeast erg26p. FR171456 specifically targets the sterol-4-alpha-carboxylate-3-dehydrogenase (Saccharomyces cerevisiae—Erg26p, Homo sapiens—NSDHL (NAD(P) dependent steroid dehydrogenase-like)), an essential enzyme in the ergosterol/cholesterol biosynthesis pathway. FR171456 significantly alters the levels of cholesterol pathway intermediates in human and yeast cells.

Chemical Structure

FR171456

CAS#168986-58-1

Theoretical Analysis

MedKoo Cat#: 565484

Name: FR171456

CAS#: 168986-58-1

Chemical Formula:

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis:

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FR171456; FR 171456; FR-171456; (+)-WF 15604A; WF 15604A; WF-15604A; WF15604A;

IUPAC/Chemical Name

3beta,8alpha,11alpha-Trihydroxy-4-methyl-1,6-dioxo-9beta,19-cyclo-5alpha-ergost-24(28)-ene-4alpha-carboxylic acid

InChi Key

JAHGNOXPMXOEJS-BSPLYONXSA-N

InChi Code

InChI=1S/C30H44O7/c1-15(2)16(3)7-8-17(4)18-9-10-20-26(18,5)13-23(34)29-14-28(29)22(33)11-21(32)27(6,25(35)36)24(28)19(31)12-30(20,29)37/h15,17-18,20-21,23-24,32,34,37H,3,7-14H2,1-2,4-6H3,(H,35,36)/t17-,18-,20-,21+,23-,24+,26-,27-,28+,29+,30+/m1/s1

SMILES Code

C=C(C(C)C)CC[C@@H](C)[C@H]([C@]1(C[C@@H](O)[C@@]23[C@@]45C3)C)CC[C@@]1([H])[C@@]2(O)CC([C@@]5([H])[C@@](C(O)=O)(C)[C@@H](O)CC4=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Helliwell SB, Karkare S, Bergdoll M, Rahier A, Leighton-Davis JR, Fioretto C, Aust T, Filipuzzi I, Frederiksen M, Gounarides J, Hoepfner D, Hofmann A, Imbert PE, Jeker R, Knochenmuss R, Krastel P, Margerit A, Memmert K, Miault CV, Rao Movva N, Muller A, Naegeli HU, Oberer L, Prindle V, Riedl R, Schuierer S, Sexton JA, Tao J, Wagner T, Yin H, Zhang J, Roggo S, Reinker S, Parker CN. FR171456 is a specific inhibitor of mammalian NSDHL and yeast Erg26p. Nat Commun. 2015 Oct 12;6:8613. doi: 10.1038/ncomms9613. PubMed PMID: 26456460; PubMed Central PMCID: PMC4633953. 2: Hatori H, Shibata T, Nishikawa M, Ueda H, Hino M, Fujii T. FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. II. Biological activities. J Antibiot (Tokyo). 2004 Apr;57(4):260-3. PubMed PMID: 15217190. 3: Hatori H, Shibata T, Tsurumi Y, Nakanishi T, Katsuoka M, Ohtsu Y, Sakamoto K, Takase S, Ueda H, Hino M, Fujii T. FR171456, a novel cholesterol synthesis inhibitor produced by Sporormiella minima No. 15604. I. Taxonomy, fermentation, isolation, physico-chemical properties. J Antibiot (Tokyo). 2004 Apr;57(4):253-9. PubMed PMID: 15217189.