FR-901459 | CAS# 153049-50-4 | Biochemical

MedKoo Cat#: 575695 | Name: FR-901459

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-901459 is a cyclosporine derivative that prolongs survival time of skin allografts.

Chemical Structure

FR-901459

CAS#153049-50-4

Theoretical Analysis

MedKoo Cat#: 575695

Name: FR-901459

CAS#: 153049-50-4

Chemical Formula: C62H111N11O13

Exact Mass: 1217.8363

Molecular Weight: 1218.63

Elemental Analysis: C, 61.11; H, 9.18; N, 12.64; O, 17.07

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

FR901459; FR-901459; FR 901459

IUPAC/Chemical Name

(2S)-N-((3S,E)-4-((3S,8S)-6-(L-alanyl-D-alanyl)-2,5,10-trimethyl-8-((S)-4-methyl-2-(methylamino)pentanamido)-3-(methylamino)-4,7-dioxoundec-10-en-5-yl)-4-(L-threonyl)-3-formyl-7-hydroxy-8-methyl-1,6-bis(methylamino)-2,5-dioxododec-10-en-3-yl)-N,4-dimethyl-2-((S)-4-methyl-2-(methylamino)pentanamido)pentanamide

InChi Key

AABGNJDJKXZYRE-YOIDXIJTSA-N

InChi Code

InChI=1S/C62H111N11O13/c1-23-24-25-37(12)50(77)49(69-21)55(82)62(53(80)47(64)40(15)75,61(31-74,45(76)30-65-17)73(22)59(86)44(29-35(8)9)72-58(85)43(67-19)28-34(6)7)60(16,54(81)48(68-20)36(10)11)46(51(78)39(14)70-56(83)38(13)63)52(79)41(26-32(2)3)71-57(84)42(66-18)27-33(4)5/h23-24,31,33-44,46-50,65-69,75,77H,2,25-30,63-64H2,1,3-22H3,(H,70,83)(H,71,84)(H,72,85)/b24-23+/t37?,38-,39+,40+,41-,42-,43-,44-,46?,47-,48-,49?,50?,60?,61-,62?/m0/s1

SMILES Code

CNCC(=O)[C@](C=O)(N(C)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC)C(C(=O)[C@@H](N)[C@@H](C)O)(C(=O)C(NC)C(O)C(C)C\C=C\C)C(C)(C(C(=O)[C@@H](C)NC(=O)[C@H](C)N)C(=O)[C@H](CC(=C)C)NC(=O)[C@H](CC(C)C)NC)C(=O)[C@@H](NC)C(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,218.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Muramatsu Y, Furuichi Y, Tojo N, Moriguchi A, Maemoto T, Nakada H, Hino M, Matsuoka N. Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models. Brain Res. 2007 May 29;1149:181-90. doi: 10.1016/j.brainres.2007.02.036. Epub 2007 Feb 24. PMID: 17391653.