IDT | CAS#18138-19-7 | TNFα modulator

MedKoo Cat#: 563487 | Name: IDT

Description:

WARNING: This product is for research use only, not for human or veterinary use.

IDT is an oral TNFα modulator. It acts by altering neutrophil infiltration, improving cognition and diminishing tau and amyloid pathology in the 3xTgAD mouse model.

Chemical Structure

IDT

CAS#18138-19-7

Theoretical Analysis

MedKoo Cat#: 563487

Name: IDT

CAS#: 18138-19-7

Chemical Formula: C8H5NS2

Exact Mass: 178.9863

Molecular Weight: 179.25

Elemental Analysis: C, 53.60; H, 2.81; N, 7.81; S, 35.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

IDT;

IUPAC/Chemical Name

Isoindolin-1,3-dithione

InChi Key

CMTSCLKCQBPLSH-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H5NS2/c10-7-5-3-1-2-4-6(5)8(11)9-7/h1-4H,(H,9,10,11)

SMILES Code

S=C1NC(C2=C1C=CC=C2)=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 179.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: McGill M, Blonde L, Chan JCN, Khunti K, Lavalle FJ, Bailey CJ; Global Partnership for Effective Diabetes Management. The interdisciplinary team in type 2 diabetes management: Challenges and best practice solutions from real-world scenarios. J Clin Transl Endocrinol. 2016 Dec 9;7:21-27. doi: 10.1016/j.jcte.2016.12.001. eCollection 2017 Mar. Review. PubMed PMID: 29067246; PubMed Central PMCID: PMC5651292. 2: Tiberi S, Carvalho AC, Sulis G, Vaghela D, Rendon A, Mello FC, Rahman A, Matin N, Zumla A, Pontali E. The cursed duet today: Tuberculosis and HIV-coinfection. Presse Med. 2017 Mar;46(2 Pt 2):e23-e39. doi: 10.1016/j.lpm.2017.01.017. Epub 2017 Feb 28. Review. PubMed PMID: 28256380. 3: Iwamura A, Nakajima M, Oda S, Yokoi T. Toxicological potential of acyl glucuronides and its assessment. Drug Metab Pharmacokinet. 2017 Feb;32(1):2-11. doi: 10.1016/j.dmpk.2016.11.002. Epub 2016 Nov 23. Review. PubMed PMID: 28017536. 4: Hirayama N. Docking simulations between drugs and HLA molecules associated with idiosyncratic drug toxicity. Drug Metab Pharmacokinet. 2017 Feb;32(1):31-39. doi: 10.1016/j.dmpk.2016.10.002. Epub 2016 Oct 18. Review. PubMed PMID: 27964952. 5: Heinemann L, Drossel D, Freckmann G, Kulzer B. Usability of Medical Devices for Patients With Diabetes Who Are Visually Impaired or Blind. J Diabetes Sci Technol. 2016 Nov 1;10(6):1382-1387. Print 2016 Nov. Review. PubMed PMID: 27605593; PubMed Central PMCID: PMC5094343. 6: Moore AR, Bastian RG, Apenteng BA. Communication Within Hospice Interdisciplinary Teams: A Narrative Review. Am J Hosp Palliat Care. 2016 Dec;33(10):996-1012. Epub 2015 Oct 30. Review. PubMed PMID: 26518351. 7: Barbaud A, Waton J. Systemic Allergy to Corticosteroids: Clinical Features and Cross Reactivity. Curr Pharm Des. 2016;22(45):6825-6831. doi: 10.2174/1381612822666161013092339. Review. PubMed PMID: 27739370. 8: Fathi R, Sheehan OC, Garrigues SK, Saliba D, Leff B, Ritchie CS. Development of an Interdisciplinary Team Communication Framework and Quality Metrics for Home-Based Medical Care Practices. J Am Med Dir Assoc. 2016 Aug 1;17(8):725-729.e10. doi: 10.1016/j.jamda.2016.03.018. Epub 2016 May 20. Review. PubMed PMID: 27217093. 9: de Ridder M, Kim J, Jing Y, Khadra M, Nanan R. A systematic review on incentive-driven mobile health technology: As used in diabetes management. J Telemed Telecare. 2017 Jan;23(1):26-35. doi: 10.1177/1357633X15625539. Epub 2016 Jul 9. Review. PubMed PMID: 26888421. 10: Rossi S, Staubach C, Blome S, Guberti V, Thulke HH, Vos A, Koenen F, Le Potier MF. Controlling of CSFV in European wild boar using oral vaccination: a review. Front Microbiol. 2015 Oct 23;6:1141. doi: 10.3389/fmicb.2015.01141. eCollection 2015. Review. PubMed PMID: 26557109; PubMed Central PMCID: PMC4615961. 11: Müller T, Freuling CM, Wysocki P, Roumiantzeff M, Freney J, Mettenleiter TC, Vos A. Terrestrial rabies control in the European Union: historical achievements and challenges ahead. Vet J. 2015 Jan;203(1):10-7. doi: 10.1016/j.tvjl.2014.10.026. Epub 2014 Oct 23. Review. PubMed PMID: 25466578. 12: Partnership for Health in Aging Workgroup on Interdisciplinary Team Training in Geriatrics. Position statement on interdisciplinary team training in geriatrics: an essential component of quality health care for older adults. J Am Geriatr Soc. 2014 May;62(5):961-5. doi: 10.1111/jgs.12822. Epub 2014 Apr 16. Review. PubMed PMID: 24738753. 13: Olivry T, Saridomichelakis M; International Committee on Atopic Diseases of Animals (ICADA). Evidence-based guidelines for anti-allergic drug withdrawal times before allergen-specific intradermal and IgE serological tests in dogs. Vet Dermatol. 2013 Apr;24(2):225-e49. doi: 10.1111/vde.12016. Epub 2013 Feb 12. Review. PubMed PMID: 23402664. 14: Vos A, Nunan C, Bolles D, Müller T, Fooks AR, Tordo N, Baer GM. The occurrence of rabies in pre-Columbian Central America: an historical search. Epidemiol Infect. 2011 Oct;139(10):1445-52. doi: 10.1017/S0950268811001440. Epub 2011 Jul 29. Review. PubMed PMID: 21798107. 15: Lewis AF, Franzese C, Stringer SP. Diagnostic evaluation of inhalant allergies: a cost-effectiveness analysis. Am J Rhinol. 2008 May-Jun;22(3):246-52. doi: 10.2500/ajr.2008.22.3163. Review. PubMed PMID: 18588756. 16: Dürrwald R, Kolodziejek J, Herzog S, Nowotny N. Meta-analysis of putative human bornavirus sequences fails to provide evidence implicating Borna disease virus in mental illness. Rev Med Virol. 2007 May-Jun;17(3):181-203. Review. PubMed PMID: 17342788. 17: Dürrwald R, Kolodziejek J, Muluneh A, Herzog S, Nowotny N. Epidemiological pattern of classical Borna disease and regional genetic clustering of Borna disease viruses point towards the existence of to-date unknown endemic reservoir host populations. Microbes Infect. 2006 Mar;8(3):917-29. Epub 2006 Jan 6. Review. PubMed PMID: 16469519. 18: Vos A. Oral vaccination against rabies and the behavioural ecology of the red fox (Vulpes vulpes). J Vet Med B Infect Dis Vet Public Health. 2003 Dec;50(10):477-83. Review. PubMed PMID: 14720184. 19: Barbaud A. [The use of skin testing in the investigation of toxidermia: from pathophysiology to the results of skin testing]. Therapie. 2002 May-Jun;57(3):258-62. Review. French. PubMed PMID: 12422538. 20: Moneret-Vautrin DA, Kanny G. Anaphylaxis to muscle relaxants: rational for skin tests. Allerg Immunol (Paris). 2002 Sep;34(7):233-40. Review. PubMed PMID: 12389445.