Synonym
Karphos; HSDB6692; HSDB 6692; HSDB-6692; Isoxathion; SI-6711; SI 6711; SI6711;
IUPAC/Chemical Name
O,O-Diethyl O-5-phenylisoxazol-3-ylphosphorothioate
InChi Key
SDMSCIWHRZJSRN-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H16NO4PS/c1-3-15-19(20,16-4-2)18-13-10-12(17-14-13)11-8-6-5-7-9-11/h5-10H,3-4H2,1-2H3
SMILES Code
S=P(OCC)(OCC)OC1=NOC(C2=CC=CC=C2)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
313.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Sakaguchi K, Nagayama M, Masaoka T, Nishimura A, Kageyama K, Shirai M, Akahori F. Effects of fenthion, isoxathion, dichlorvos and propaphos on the serum cholinesterase isoenzyme patterns of dogs. Vet Hum Toxicol. 1997 Feb;39(1):1-5. PubMed PMID: 9004458.
2: Ageda S, Fuke C, Ihama Y, Miyazaki T. The stability of organophosphorus insecticides in fresh blood. Leg Med (Tokyo). 2006 May;8(3):144-9. Epub 2006 Mar 3. PubMed PMID: 16517205.
3: Thurman EM, Ferrer I, Zavitsanos P, Zweigenbaum JA. Analysis of isobaric pesticides in pepper with high-resolution liquid chromatography and mass spectrometry: complementary or redundant? J Agric Food Chem. 2013 Mar 13;61(10):2340-7. doi: 10.1021/jf304642g. Epub 2013 Jan 29. PubMed PMID: 23305249.
4: Kitamura K, Maruyama K, Hamano S, Kishi T, Kawakami T, Takahashi Y, Onodera S. Effect of hypochlorite oxidation on cholinesterase-inhibition assay of acetonitrile extracts from fruits and vegetables for monitoring traces of organophosphate pesticides. J Toxicol Sci. 2014 Feb;39(1):71-81. PubMed PMID: 24418711.
5: Kanno A, Kawakami T, Takahashi Y, Onodera S. Enhancement of anti-cholinesterase activity of aqueous samples by hypochlorite oxidation for monitoring traces of organophosphorus pesticides in water. J Toxicol Sci. 2012;37(2):389-400. PubMed PMID: 22467030.
6: Ohno K, Minami T, Matsui Y, Magara Y. Effects of chlorine on organophosphorus pesticides adsorbed on activated carbon: desorption and oxon formation. Water Res. 2008 Mar;42(6-7):1753-9. Epub 2007 Nov 6. PubMed PMID: 18048077.
7: Ueno E, Oshima H, Saito I, Matsumoto H. [Multiresidue analysis of organophosphorus pesticides in vegetables and fruits using dual-column GC-FPD, -NPD]. Shokuhin Eiseigaku Zasshi. 2001 Dec;42(6):385-93. Japanese. PubMed PMID: 11875824.
8: Yamanaka S, Yoshida M, Yamamura Y, Nishimura M, Takaesu Y. [A study on acute organophosphorus poisoning--changes in the activity and isoenzyme patterns of serum cholinesterase in human poisoning]. Nihon Eiseigaku Zasshi. 1993 Dec;48(5):955-65. Japanese. PubMed PMID: 8107298.
9: Takeuchi S, Iida M, Yabushita H, Matsuda T, Kojima H. In vitro screening for aryl hydrocarbon receptor agonistic activity in 200 pesticides using a highly sensitive reporter cell line, DR-EcoScreen cells, and in vivo mouse liver cytochrome P450-1A induction by propanil, diuron and linuron. Chemosphere. 2008 Dec;74(1):155-65. doi: 10.1016/j.chemosphere.2008.08.015. Epub 2008 Oct 5. PubMed PMID: 18835618.
