Synonym
Aladotrilat; Fasidotrilat;
IUPAC/Chemical Name
((S)-3-(benzo[d][1,3]dioxol-5-yl)-2-(mercaptomethyl)propanoyl)-L-alanine
InChi Key
TXSINLUUGRGAJO-WCBMZHEXSA-N
InChi Code
InChI=1S/C14H17NO5S/c1-8(14(17)18)15-13(16)10(6-21)4-9-2-3-11-12(5-9)20-7-19-11/h2-3,5,8,10,21H,4,6-7H2,1H3,(H,15,16)(H,17,18)/t8-,10+/m0/s1
SMILES Code
C[C@@H](C(O)=O)NC([C@@H](CS)CC1=CC=C(OCO2)C2=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
311.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ul-Haq Z, Usmani S, Iqbal S, Zia SR. In silico based investigation of dynamic variations in neprilysin (NEP and NEP2) proteins for extracting the point of specificity. Mol Biosyst. 2016 Mar;12(3):1024-36. doi: 10.1039/c5mb00727e. PubMed PMID: 26846903.
2: Machowska A, Juszczak K, Novak P, Thor P. The natriuretic peptide neurohormonal system modulation by vasopeptidase inhibitors--the novel therapeutical approach of hypertension treatment. Folia Med Cracov. 2009;50(3-4):35-42. Review. PubMed PMID: 21853869.
3: Marie C, Mossiat C, Lecomte JM, Bralet J. Acute natriuretic effect of fasidotrilat, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in rats with heart failure. Pharmacology. 1998 Jun;56(6):291-6. PubMed PMID: 9654215.
4: Marie C, Mossiat C, Lecomte JM, Schwartz JC, Bralet J. Hemodynamic effects of acute and chronic treatment with aladotril, a mixed inhibitor of neutral endopeptidase and angiotensin I-converting enzyme, in conscious rats with myocardial infarction. J Pharmacol Exp Ther. 1995 Dec;275(3):1324-31. PubMed PMID: 8531099.
