Pyrintegrin is a cell-permeable promoter of the adhesion of individually dissociated hESCs on matrigel- or laminin-, but not gelatin-coated surfaces, substantially reducing trypsinization-induced apoptosis. Pyrintegrin is known to promote embryonic stem cells survival, is robustly adipogenic and induces postnatal adipose tissue formation in vivo of transplanted adipose stem/progenitor cells (ASCs) and recruited endogenous cells. In vitro, Pyrintegrin stimulated human adipose tissue derived ASCs to differentiate into lipid-laden adipocytes by upregulating peroxisome proliferator-activated receptor (PPARγ) and CCAAT/enhancer-binding protein-α (C/EBPα), with differentiated cells increasingly secreting adiponectin, leptin, glycerol and total triglycerides.
MedKoo Cat#: 562951
Name: Pyrintegrin
CAS#: 1228445-38-2
Chemical Formula: C23H25N5O3S
Exact Mass: 451.1678
Molecular Weight: 451.54
Elemental Analysis: C, 61.18; H, 5.58; N, 15.51; O, 10.63; S, 7.10
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 50.0 | 110.73 | |
| DMSO | 30.0 | 66.44 | |
| Ethanol | 1.0 | 2.21 |
The following data is based on the product molecular weight 451.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
