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MedKoo Cat#: 596757 | Name: Acyclovir alaninate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acyclovir alaninate is a pro-drug of Acyclovir. Acyclovir is a nucleic acid analog made from guanosine and is used in the treatment of chickenpox, shingles, and herpes simplex virus. Acyclovir works by decreasing the production of DNA of the virus and i shows very low cytotoxicity.

Chemical Structure

Acyclovir alaninate
Acyclovir alaninate
CAS#84499-64-9

Theoretical Analysis

MedKoo Cat#: 596757

Name: Acyclovir alaninate

CAS#: 84499-64-9

Chemical Formula: C11H16N6O4

Exact Mass: 296.1233

Molecular Weight: 296.28

Elemental Analysis: C, 44.59; H, 5.44; N, 28.37; O, 21.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Acyclovir alaninate; Valacyclovir hydrochloride, acyclovir alaninated- [USP];
IUPAC/Chemical Name
2-((2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)ethyl L-alaninate
InChi Key
MUIRAGHHRGAJMO-LURJTMIESA-N
InChi Code
InChI=1S/C11H16N6O4/c1-6(12)10(19)21-3-2-20-5-17-4-14-7-8(17)15-11(13)16-9(7)18/h4,6H,2-3,5,12H2,1H3,(H3,13,15,16,18)/t6-/m0/s1
SMILES Code
N[C@@H](C)C(OCCOCN1C=NC2=C1N=C(N)NC2=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 296.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kusulja M, Santini M. Decompressive craniectomy as salvage treatment in herpes simplex encephalitis: two case reports. Int J Infect Dis. 2018 Jun 2. pii: S1201-9712(18)34426-6. doi: 10.1016/j.ijid.2018.05.016. [Epub ahead of print] PubMed PMID: 29870796. 2: Tintori C, Iovenitti G, Ceresola ER, Ferrarese R, Zamperini C, Brai A, Poli G, Dreassi E, Cagno V, Lembo D, Canducci F, Botta M. Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides. PLoS One. 2018 Jun 5;13(6):e0198478. doi: 10.1371/journal.pone.0198478. eCollection 2018. PubMed PMID: 29870553. 3: White CN, Jones G, Baker S, Dean RS, Brennan ML. Variation in the Reported Management of Canine Prolapsed Nictitans Gland and Feline Herpetic Keratitis. Vet Sci. 2018 Jun 1;5(2). pii: E54. doi: 10.3390/vetsci5020054. PubMed PMID: 29865183. 4: Vallabhaneni D, Naveed MA, Mangla R, Zidan A, Mehta RI. Perfusion Imaging in Autoimmune Encephalitis. Case Rep Radiol. 2018 May 6;2018:3538645. doi: 10.1155/2018/3538645. eCollection 2018. PubMed PMID: 29854534; PubMed Central PMCID: PMC5960559. 5: Faqih NA, Alfaqih MA, Salami K, Herron B, Sultan I, Al-Hussaini M. Empirical treatment with parenteral acyclovir in a child with herpes simplex virus hepatitis and acute lymphoblastic leukemia. IDCases. 2018 Feb 21;12:10-12. doi: 10.1016/j.idcr.2018.02.006. eCollection 2018. PubMed PMID: 29850402; PubMed Central PMCID: PMC5966627. 6: Inagaki T, Satoh M, Fujii H, Yamada S, Shibamura M, Yoshikawa T, Harada S, Takeyama H, Saijo M. Acyclovir Sensitivity and Neurovirulence of Herpes Simplex Virus Type 1 with Amino Acid Substitutions in the Viral Thymidine Kinase Gene, Which Were Detected in the Patients with Intractable Herpes Simplex Encephalitis Previously Reported. Jpn J Infect Dis. 2018 May 31. doi: 10.7883/yoken.JJID.2018.176. [Epub ahead of print] PubMed PMID: 29848849. 7: Alexander KE, Tong PL, Macartney K, Beresford R, Sheppeard V, Gupta M. Live zoster vaccination in an immunocompromised patient leading to death secondary to disseminated varicella zoster virus infection. Vaccine. 2018 May 25. pii: S0264-410X(18)30744-8. doi: 10.1016/j.vaccine.2018.05.078. [Epub ahead of print] PubMed PMID: 29807711. 8: Siodlak M, Jorgenson MR, Descourouez JL, Leverson GE, Mandelbrot DA, Smith JA, Redfield RR. Impact of High-Dose Acyclovir Cytomegalovirus Prophylaxis Failure in Abdominal Solid Organ Transplant Recipients. Pharmacotherapy. 2018 May 25. doi: 10.1002/phar.2126. [Epub ahead of print] PubMed PMID: 29800500. 9: Vestergaard T. [Genital herpes]. Ugeskr Laeger. 2018 May 14;180(20). pii: V01180024. Danish. PubMed PMID: 29798750. 10: Pines N, Tsabari R, Kerem E, Reiter J. Herpes Simplex Virus Pneumonia in an Immunocompetent Child on Corticosteroids for Acute Wheezing. Pediatr Emerg Care. 2018 May 23. doi: 10.1097/PEC.0000000000001519. [Epub ahead of print] PubMed PMID: 29794958. 11: Lebrun M, Lambert J, Riva L, Thelen N, Rambout X, Blondeau C, Thiry M, Snoeck R, Twizere JC, Dequiedt F, Andrei G, Sadzot-Delvaux C. Varicella Zoster Virus ORF9p binding to cellular adaptor protein complex-1 is important for viral infectivity. J Virol. 2018 May 23. pii: JVI.00295-18. doi: 10.1128/JVI.00295-18. [Epub ahead of print] PubMed PMID: 29793951. 12: Uthayakumar A, Harrington D. Spontaneous splenic rupture complicating primary varicella zoster infection: a case report. BMC Res Notes. 2018 May 22;11(1):334. doi: 10.1186/s13104-018-3430-6. PubMed PMID: 29789000; PubMed Central PMCID: PMC5964893. 13: Mäkitie O, Vakkilainen S. Cartilage-Hair Hypoplasia – Anauxetic Dysplasia Spectrum Disorders. 2012 Mar 15 [updated 2018 May 24]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2018. Available from http://www.ncbi.nlm.nih.gov/books/NBK84550/ PubMed PMID: 22420014. 14: Begolli Gerqari A, Ferizi M, Kotori M, Daka A, Hapciu S, Begolli I, Begolli M, Gerqari I. Activation of Herpes Simplex Infection after Tattoo. Acta Dermatovenerol Croat. 2018 Apr;26(1):75-76. PubMed PMID: 29782308. 15: Vissani MA, Zabal O, Tordoya MS, Parreño V, Thiry E, Barrandeguy M. In vitro comparison of acyclovir, ganciclovir and cidofovir against equid alphaherpesvirus 3 and evaluation of their efficacy against six field isolates. Rev Argent Microbiol. 2018 May 17. pii: S0325-7541(18)30005-1. doi: 10.1016/j.ram.2018.01.003. [Epub ahead of print] PubMed PMID: 29779880. 16: Chayrov RL, Stylos EK, Chatziathanasiadou MV, Chuchkov KN, Tencheva AI, Kostagianni AD, Milkova TS, Angelova AL, Galabov AS, Shishkov SA, Todorov DG, Tzakos AG, Stankova IG. Tailoring acyclovir prodrugs with enhanced antiviral activity: rational design, synthesis, human plasma stability and in vitro evaluation. Amino Acids. 2018 May 19. doi: 10.1007/s00726-018-2590-y. [Epub ahead of print] PubMed PMID: 29779181. 17: Abozaid D, Ramadan A, Barakat H, Khalafallah N. Acyclovir lipid nanocapsules gel for oromucosal delivery: A preclinical evidence of efficacy in the chicken pouch membrane model. Eur J Pharm Sci. 2018 May 17. pii: S0928-0987(18)30235-5. doi: 10.1016/j.ejps.2018.05.016. [Epub ahead of print] PubMed PMID: 29778782. 18: Gagelmann N, Ljungman P, Styczynski J, Kröger N. Comparative Efficacy and Safety of Different Antiviral Agents for Cytomegalovirus Prophylaxis in Allogeneic Hematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis. Biol Blood Marrow Transplant. 2018 May 16. pii: S1083-8791(18)30269-6. doi: 10.1016/j.bbmt.2018.05.017. [Epub ahead of print] PubMed PMID: 29777868. 19: Pamornpathomkul B, Ngawhirunpat T, Tekko IA, Vora L, McCarthy HO, Donnelly RF. Dissolving polymeric microneedle arrays for enhanced site-specific acyclovir delivery. Eur J Pharm Sci. 2018 May 16;121:200-209. doi: 10.1016/j.ejps.2018.05.009. [Epub ahead of print] PubMed PMID: 29777854. 20: Lubián López S, Pérez Guerrero JJ, Salazar Oliva P, Benavente Fernández I. [Neonatal facial palsy: identification of herpes simplex virus 1 in cerebrospinal fluid. Case report]. Arch Argent Pediatr. 2018 Jun 1;116(3):e468-e470. doi: 10.5546/aap.2018.e468. Spanish. PubMed PMID: 29756726.