Lorajmine | CAS#47562-08-3 | antiarrhythmic agent

MedKoo Cat#: 592328 | Name: Lorajmine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lorajmine is a monochloroacetyl derivative of ajmaline. It is a class Ia antiarrhythmic agent that is rapidly hydrolyzed to ajmaline by plasma and tissue esterases.

Chemical Structure

Lorajmine

CAS#47562-08-3

Theoretical Analysis

MedKoo Cat#: 592328

Name: Lorajmine

CAS#: 47562-08-3

Chemical Formula: C22H27ClN2O3

Exact Mass: 402.1710

Molecular Weight: 402.92

Elemental Analysis: C, 65.58; H, 6.75; Cl, 8.80; N, 6.95; O, 11.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Lorajmine; Lorajmina

IUPAC/Chemical Name

Ajmalan-17,21-diol, 17-(chloroacetate)

InChi Key

LAHDERDHXJFFJU-ASFGTCIHSA-N

InChi Code

InChI=1S/C22H27ClN2O3/c1-3-11-12-8-15-19-22(13-6-4-5-7-14(13)24(19)2)9-16(25(15)21(11)27)18(12)20(22)28-17(26)10-23/h4-7,11-12,15-16,18-21,27H,3,8-10H2,1-2H3/t11-,12-,15-,16-,18-,19-,20+,21?,22+/m0/s1

SMILES Code

CN1[C@]2([C@@]3(C[C@H]4[C@@H](C(O)N3[C@@H]5[C@H]4[C@@H](OC(CCl)=O)[C@@]2(C6=C1C=CC=C6)C5)CC)[H])[H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 402.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Padrini R, Piovan D, Gaglione E, Zordan R, Ferrari M. Determination of lorajmine and its metabolite ajmaline in plasma and urine by a new high-performance liquid chromatographic method. Ther Drug Monit. 1992 Oct;14(5):391-6. PubMed PMID: 1448847. 2: Lanza GA, Rebuzzi AG, Santarelli P, Tamburi S, Lucente M. [Bidirectional tachycardia during therapy with lorajmine]. Cardiologia. 1989 Oct;34(10):893-6. Italian. PubMed PMID: 2605577. 3: Furlanello F, Gramegna L, Dal Forno P, Vergara G, Bettini R, Inama G, Disertori M. Worsening of arrhythmias during pharmacological treatment. G Ital Cardiol. 1984 Oct;14(10):798-803. PubMed PMID: 6440827. 4: Cafiero M, Buono G, D'Oriano R, Landmann E, Santoro R. [On the effects of lorajmine on ventricular and supraventricular extrasystolic arrhythmias. Study with the Holter method]. Minerva Cardioangiol. 1984 Jan-Feb;32(1-2):59-66. Italian. PubMed PMID: 6201786. 5: Sanna G, Meoli P, Bianchini C, Rovelli F. Antiarrhythmic effectiveness of propafenone compared to lorajmine in ventricular arrhythmias. Controlled clinical trial. G Ital Cardiol. 1983;13(3):145-51. PubMed PMID: 6350090.