L 669083 | CAS#130007-52-2 | biosynthesis inhibitor

MedKoo Cat#: 596619 | Name: L 669083

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 669083 is a photoaffinity analogue of two classes of potent leukotriene biosynthesis inhibitors.

Chemical Structure

L 669083

CAS#130007-52-2

Theoretical Analysis

MedKoo Cat#: 596619

Name: L 669083

CAS#: 130007-52-2

Chemical Formula: C29H29IN4O5S

Exact Mass: 672.0903

Molecular Weight: 672.53

Elemental Analysis: C, 51.79; H, 4.35; I, 18.87; N, 8.33; O, 11.89; S, 4.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 669083; L-669083; L669083; L-669,083; L 669,083; L669,083;

IUPAC/Chemical Name

3-(3-((4-azidophenyl)sulfonyl)-1-(4-hydroxy-3-iodobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

InChi Key

AKCMQYDDRKIENA-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H29IN4O5S/c1-17(2)19-6-11-24-22(14-19)27(40(38,39)21-9-7-20(8-10-21)32-33-31)25(15-29(3,4)28(36)37)34(24)16-18-5-12-26(35)23(30)13-18/h5-14,17,35H,15-16H2,1-4H3,(H,36,37)

SMILES Code

O=C(O)C(C)(C)CC(N1CC2=CC=C(O)C(I)=C2)=C(S(=O)(C3=CC=C(N=[N+]=[N-])C=C3)=O)C4=C1C=CC(C(C)C)=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 672.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Vickers PJ, Adam M, Charleson S, Coppolino MG, Evans JF, Mancini JA. Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Jul;42(1):94-102. PubMed PMID: 1635556. 2: Mancini JA, Prasit P, Coppolino MG, Charleson P, Leger S, Evans JF, Gillard JW, Vickers PJ. 5-Lipoxygenase-activating protein is the target of a novel hybrid of two classes of leukotriene biosynthesis inhibitors. Mol Pharmacol. 1992 Feb;41(2):267-72. PubMed PMID: 1538707. 3: Reid GK, Kargman S, Vickers PJ, Mancini JA, Léveillé C, Ethier D, Miller DK, Gillard JW, Dixon RA, Evans JF. Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis. J Biol Chem. 1990 Nov 15;265(32):19818-23. PubMed PMID: 2174053. 4: Miller DK, Gillard JW, Vickers PJ, Sadowski S, Léveillé C, Mancini JA, Charleson P, Dixon RA, Ford-Hutchinson AW, Fortin R, et al. Identification and isolation of a membrane protein necessary for leukotriene production. Nature. 1990 Jan 18;343(6255):278-81. PubMed PMID: 2300172.