Synonym
NSC 283448; NSC-283448; NSC283448; Tolnidamine;
IUPAC/Chemical Name
1H-Indazole-3-carboxylic acid, 1-(4-chloro-2-methylbenzyl)-
InChi Key
IWKDFIXLGQOEKD-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H13ClN2O2/c1-10-8-12(17)7-6-11(10)9-19-14-5-3-2-4-13(14)15(18-19)16(20)21/h2-8H,9H2,1H3,(H,20,21)
SMILES Code
O=C(C1=NN(CC2=CC=C(Cl)C=C2C)C3=C1C=CC=C3)O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
300.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ansari AS, Kumar Y, Srivastava S, Lohiya NK. Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits. Contraception. 1998 Apr;57(4):271-9. PubMed PMID: 9649920.
2: Lohiya NK, Ansari AS, Scorza Barcellona P. Antispermatogenic effects of tolnidamine in langur (Presbytis entellus). Contraception. 1991 May;43(5):485-96. PubMed PMID: 1914461.
3: Rossi V, Cheng CY, Gunsalus GL, Bardin CW, Spitz IM. The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion. J Androl. 1989 Nov-Dec;10(6):466-71. PubMed PMID: 2621153.
4: Wu FC. Male contraception: current status and future prospects. Clin Endocrinol (Oxf). 1988 Oct;29(4):443-65. Review. PubMed PMID: 3075164.
5: Spitz IM, Gunsalus GL, Mather JP, Thau R, Bardin CW. The effects of the indazole carboxylic acid derivative, tolnidamine, on testicular function: I. Early changes in androgen binding protein secretion in the rat. J Androl. 1985 May-Jun;6(3):171-8. PubMed PMID: 3922932.
6: Heywood R, James RW, Barcellona PS, Campana A, Cioli V. Toxicological studies on 1-substituted-indazole-3-carboxylic acids. Chemotherapy. 1981;27 Suppl 2:91-7. PubMed PMID: 7285641.
7: Silvestrini B. Basic and applied research in the study of indazole carboxylic acids. Chemotherapy. 1981;27 Suppl 2:9-20. PubMed PMID: 6793319.
8: Lobl TJ, Bardin CW, Gunsalus GL, Musto NA. Effects of Lonidamine (AF 1890) and its analogues on follicle-stimulating hormone, luteinizing hormone, testosterone and rat androgen binding protein concentrations in the rat and rhesus monkey. Chemotherapy. 1981;27 Suppl 2:61-76. PubMed PMID: 6793318.
