MedKoo Cat#: 596430 | Name: D-Epinephrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D-Epinephrine is a hormone, neurotransmitter, and medication. Epinephrine is normally produced by both the adrenal glands and certain neurons. It plays an important role in the fight-or-flight response by increasing blood flow to muscles, output of the heart, pupil dilation, and blood sugar. It does this by binding to alpha and beta receptors.

Chemical Structure

D-Epinephrine
D-Epinephrine
CAS#150-05-0

Theoretical Analysis

MedKoo Cat#: 596430

Name: D-Epinephrine

CAS#: 150-05-0

Chemical Formula: C9H13NO3

Exact Mass: 183.0895

Molecular Weight: 183.20

Elemental Analysis: C, 59.00; H, 7.15; N, 7.65; O, 26.20

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Synonym
D-Epinephrine; d-Adrenaline; Racepinefrine, (S)-; L-(+)-Adrenaline; (S)-adrenaline; (+)-adrenaline; (+)-epinephrine; D-(+)-Epinephrine;
IUPAC/Chemical Name
4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol
InChi Key
UCTWMZQNUQWSLP-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3
SMILES Code
CNCC(O)C1=CC=C(O)C(O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 183.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Castro-Puyana M, Drewnowska R, Pérez-Fernández V, Angeles García M, Crego AL, Marina ML. Simultaneous separation of epinephrine and norepinephrine enantiomers by EKC: application to the analysis of pharmaceutical formulations. Electrophoresis. 2009 Aug;30(16):2947-54. doi: 10.1002/elps.200900250. PubMed PMID: 19650051. 2: Juncher D, Rønn B, Beck Hansen T, Henckel P, Karlsson A, Skibsted LH, Bertelsen G. Effect of pre-slaughter physiological conditions on the oxidative stability of colour and lipid during chill storage of sliced, retail packed roast ham. Meat Sci. 2003 Feb;63(2):151-9. PubMed PMID: 22062174. 3: Li H, Luo W, Hu X. [Determination of enantiomeric purity for epinephrine by high performance liquid chromatography]. Se Pu. 1999 Jul;17(4):403-5. Chinese. PubMed PMID: 12552866. 4: Jin DR, Ma KR, Zhang XY, Wu XZ, Cui SY, Zhu YL, Toyo'Oka T. [Resolution of the epinephrine enantiomers derivatized with fluorescent chiral reagent by reversed-phase high performance liquid chromatography]. Se Pu. 2002 Jul;20(4):304-7. Chinese. PubMed PMID: 12541910. 5: Li H, Hu X, Xie Y. [Enantiomeric high performance liquid chromatographic separation of epinephrine and analogous using chiral mobile phase additives]. Se Pu. 1998 Sep;16(5):424-6. Chinese. PubMed PMID: 11498924. 6: Barber R. Forskolin binding to intact S49 lymphoma cells. Second Messengers Phosphoproteins. 1988;12(1):59-71. PubMed PMID: 3193376. 7: Gherezghiher T, Koss MC. Ocular effects of adrenergic stereoisomers in the rabbit. J Ocul Pharmacol. 1985 Spring;1(1):19-28. PubMed PMID: 3880068. 8: Hasegawa M, Townley RG. Alpha and beta adrenergic receptors of canine lung tissue identification and characterization of alpha adrenergic receptors by two different ligands. Life Sci. 1982 Mar 22;30(12):1035-44. PubMed PMID: 6280001. 9: Merkle W. [Comparative study between timolol and d-epinephrine in the treatment of open-angle glaucoma (author's transl)]. Klin Monbl Augenheilkd. 1981 Mar;178(3):203-5. German. PubMed PMID: 7014999. 10: Sokol WN, Beall GN, Kruger SR. Specificity studies of leukocytic catecholamine receptors. Int J Clin Pharmacol Biopharm. 1978 Apr;16(4):173-6. PubMed PMID: 206516. 11: Schramm M. Blocking of catecholamine activation of adenylate cyclase by N, N'dicyclohexyl carbodiimide in turkey erythrocytes. J Cyclic Nucleotide Res. 1976 Sep-Oct;2(5):347-58. PubMed PMID: 187626. a