L 158338 | CAS#133240-38-7 | angiotensin receptor antagonist

MedKoo Cat#: 596394 | Name: L 158338

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 158338 is an angiotensin receptor antagonist.

Chemical Structure

L 158338

CAS#133240-38-7

Theoretical Analysis

MedKoo Cat#: 596394

Name: L 158338

CAS#: 133240-38-7

Chemical Formula: C24H25N7

Exact Mass: 411.2171

Molecular Weight: 411.51

Elemental Analysis: C, 70.05; H, 6.12; N, 23.83

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

L 158338; L-158338; L158338;

IUPAC/Chemical Name

3-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-7-methyl-2-propyl-2,3-dihydro-1H-imidazo[4,5-b]pyridine

InChi Key

KFVPXROHNNPKMZ-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H25N7/c1-3-6-21-26-22-16(2)13-14-25-24(22)31(21)15-17-9-11-18(12-10-17)19-7-4-5-8-20(19)23-27-29-30-28-23/h4-5,7-14,21,26H,3,6,15H2,1-2H3,(H,27,28,29,30)

SMILES Code

CCCC1N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C5=NC=CC(C)=C5N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Owen RA, Molon-Noblot S, Hubert MF, Siegl PK, Eydelloth RS, Keenan KP. Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists. Lab Invest. 1994 Oct;71(4):543-51. PubMed PMID: 7967510. 2: Werrmann JG, Cohen SM. Comparison of effects of angiotensin-converting enzyme inhibition with those of angiotensin II receptor antagonism on functional and metabolic recovery in postischemic working rat heart as studied by [31P] nuclear magnetic resonance. J Cardiovasc Pharmacol. 1994 Oct;24(4):573-86. PubMed PMID: 7528840. 3: Stearns RA, Miller RR, Arison BH, Rosegay A, Smith JL, Mantlo NB, Chiu SH. Evidence for a 1,2-hydride shift in the microsomal metabolism of the heterocycle L-158,338, a nonpeptide angiotensin II receptor antagonist. Drug Metab Dispos. 1993 Jul-Aug;21(4):670-6. PubMed PMID: 8104127.