1D-2 | CAS#1635405-90-1 (racemic) | c-Met protein kinase inhibitor

MedKoo Cat#: 561264 | Name: 1D-2

Description:

WARNING: This product is for research use only, not for human or veterinary use.

1D-2 is a highly potent and exquisitely selective inhibitor of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Aberrant c-Met activation has been implicated in multiple tumor oncogenic processes and drug resistance.

Chemical Structure

1D-2

CAS#1635405-90-1 (racemic)

Theoretical Analysis

MedKoo Cat#: 561264

Name: 1D-2

CAS#: 1635405-90-1 (racemic)

Chemical Formula: C20H16FN7

Exact Mass: 373.1451

Molecular Weight: 373.40

Elemental Analysis: C, 64.33; H, 4.32; F, 5.09; N, 26.26

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

1D-2; 1D 2; 1D2

IUPAC/Chemical Name

(R)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyrazin-1-yl)ethyl)quinoline

InChi Key

SXWUXXWVCWEUTA-GFCCVEGCSA-N

InChi Code

InChI=1S/C20H16FN7/c1-12(15-6-13-4-3-5-22-17(13)7-16(15)21)28-11-24-19-20(28)26-18(9-23-19)14-8-25-27(2)10-14/h3-12H,1-2H3/t12-/m1/s1

SMILES Code

C[C@H](C1=C(F)C=C2N=CC=CC2=C1)N3C=NC4=NC=C(C5=CN(C)N=C5)N=C43

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 373.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhao F, Zhang J, Zhang L, Hao Y, Shi C, Xia G, Yu J, Liu Y. Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal-epithelial transition factor (c-Met) protein kinase. Bioorg Med Chem. 2016 Sep 15;24(18):4281-90. doi: 10.1016/j.bmc.2016.07.019. Epub 2016 Jul 12. PubMed PMID: 27448775.