A 204 | CAS# 12750-79-7 | Antibiotic

MedKoo Cat#: 571076 | Name: A 204

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A 204 is a polycyclic polyether monocarboxylic acid antibiotic. It is a crystalline isolated from fermentation of strain of Streptomyces albus.

Chemical Structure

A 204

CAS#12750-79-7

Theoretical Analysis

MedKoo Cat#: 571076

Name: A 204

CAS#: 12750-79-7

Chemical Formula: C49H84O17

Exact Mass: 944.5709

Molecular Weight: 945.19

Elemental Analysis: C, 62.27; H, 8.96; O, 28.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

A 204; A204; A-204; Antibiotic A 204; Antibiotic A-204; Antibiotic A204

IUPAC/Chemical Name

2-(2-hydroxy-6-((2-(5'-(6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)octahydro-[2,2'-bifuran]-5-yl)-3,9-dimethoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-5-methoxy-4-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoic acid

InChi Key

RHDSQRNKIIRGBB-UHFFFAOYSA-N

InChi Code

InChI=1S/C49H84O17/c1-24-40(56-13)26(3)47(10,52)65-41(24)35-17-16-33(60-35)34-18-20-37(61-34)46(9)42(57-14)28(5)49(66-46)25(2)36(55-12)22-31(63-49)23-38-45(8,58-15)43(27(4)48(53,64-38)29(6)44(50)51)62-39-21-19-32(54-11)30(7)59-39/h24-43,52-53H,16-23H2,1-15H3,(H,50,51)

SMILES Code

COC1CCC(OC2C(C)C(O)(OC(CC3CC(OC)C(C)C4(O3)OC(C)(C5CCC(O5)C6CCC(O6)C7OC(C)(O)C(C)C(OC)C7C)C(OC)C4C)C2(C)OC)C(C)C(=O)O)OC1C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 945.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fitzgerald PR. Efficacy of antibiotics A204 sodium A28695A, and A204np against Coccidia of rabbits. J Protozool. 1976 Feb;23(1):150-4. PubMed PMID: 1271305. 2: Wong DT, Horng JS, Hamill RL, Lardy HA. Effect of a new monocarboxylic acid antibiotic, A204, on the monovalent cation permeability of rat liver mitochondria. Biochem Pharmacol. 1971 Nov;20(11):3169-77. PubMed PMID: 4257133. 3: Worth HM, Meyers DB, Gibson WR, Todd GC. Acute and subacute toxicity of A204. Antimicrob Agents Chemother (Bethesda). 1970;10:357-60. PubMed PMID: 5521356. 4: Todd GC, Meyers DB, Pierce EC, Worth HM. Acute reversible myopathy produced by compound A204. Antimicrob Agents Chemother (Bethesda). 1970;10:361-5. PubMed PMID: 5521357. 5: Meyers DB, Todd GC, Gibson WR. Evidence of depletion of intracellular potassium by A204 in the rat. Antimicrob Agents Chemother (Bethesda). 1970;10:91-4. PubMed PMID: 5521379. 6: Griffing WJ, Todd GC, Pierce EC. Ultrastructural changes in rat skeletal and cardiac muscle induced by A204. Antimicrob Agents Chemother (Bethesda). 1970;10:366-73. PubMed PMID: 5521358.