Synonym
L 11204; L-11204; L11204; DL 204; DL 204IT; DL 204 IT;
IUPAC/Chemical Name
2-(3-ethoxyphenyl)-5,6-dihydro-[1,2,4]triazolo[5,1-a]isoquinoline
InChi Key
NZDDMKIDRQAGND-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17N3O/c1-2-22-15-8-5-7-14(12-15)17-19-18-16-9-4-3-6-13(16)10-11-21(18)20-17/h3-9,12H,2,10-11H2,1H3
SMILES Code
CCOC1=CC(C2=NN(CCC3=C4C=CC=C3)C4=N2)=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
291.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lerner LJ. Development of novel embryotoxic compounds for interceptive fertility control in the dog. J Reprod Fertil Suppl. 1989;39:251-65. PubMed PMID: 2621727.
2: Prasad RS, Vijayan E. A new non-hormonal antifertility drug DL-204: II. Effect on testicular hyaluronidase and gamma-glutamyl transpeptidase in male rats. Contraception. 1987 Nov;36(5):567-80. PubMed PMID: 2896099.
3: Prasad RS, Vijayan E. A new non-hormonal antifertility drug DL-204: I. Effects on testes and accessory glands of reproduction in male rats. Contraception. 1987 Nov;36(5):557-66. PubMed PMID: 2452050.
4: Galliani G, Lerner LJ, Caramel C, Maraschin R, Nani S, Nava A, Nava A. Pregnancy termination in dogs with novel non-hormonal compounds. Studies of 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL 204-IT). Arzneimittelforschung. 1982;32(2):123-7. PubMed PMID: 7199914.
5: Galliani G, Cristina T, Guzzi U, Omodei-Salé A, Assandri A. Increased oral activity of a new class of non-hormonal pregnancy terminating agents. J Pharmacobiodyn. 1982 Jan;5(1):55-61. PubMed PMID: 7077522.
6: Lerner LJ, Oldani C, Vitale A. Inhibition of superovulation and alteration of ova transportation in hamsters by prostaglandin and DL-204-IT, an anti-fertility agent. Prostaglandins Med. 1981 Apr;6(4):369-74. PubMed PMID: 7280116.
7: Assandri A, Perazzi A, Martinelli E, Ferrari P, Ripamonti A, Tuan G, Galliani G. Influence of metabolism on the activity of a new anti-fertility agent, 2-(3-ethoxyphenyl)-5,6-dihydro-s-triazolo [5,1-a]isoquinoline (DL 204-IT), in the rat and the hamster. Arzneimittelforschung. 1981;31(12):2104-11. PubMed PMID: 7199307.
8: Galliani G, Gallico L, Cattaneo C, Assandri A. Pregnancy terminating activity of a new non-hormonal anti-fertility agent, 2-(3-ethoxy-phenyl)-5,6-dihydro-s-triazole [5,1-a] isoquinoline (DL 204-IT) in the rat and the hamster. Studies on the factors affecting its activity. Arzneimittelforschung. 1980;30(6):972-7. PubMed PMID: 7191276.
9: Lerner LJ, Oldani C, Vitale A. Effects of prostaglandin E2 and DL204 IT, an inhibitor of prostaglandin degradation, on ovulation and ovum transport in the hamster. Prostaglandins. 1978 Mar;15(3):525-31. PubMed PMID: 566453.
