O 129 | CAS#3810-29-5 | vibirostatic

MedKoo Cat#: 584965 | Name: O 129

Description:

WARNING: This product is for research use only, not for human or veterinary use.

O 129 is a vibriostatic agent.

Chemical Structure

O 129

CAS#3810-29-5 (free base)

Theoretical Analysis

MedKoo Cat#: 584965

Name: O 129

CAS#: 3810-29-5 (free base)

Chemical Formula: C12H18N6

Exact Mass: 246.1593

Molecular Weight: 246.32

Elemental Analysis: C, 58.51; H, 7.37; N, 34.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

84176-65-8 (phosphate) 3810-29-5 (free base)

Synonym

AH 10639; AH-10639; AH10639; Antibiotic O-129; O 129; NSC 98771; NSC-98771; NSC98771

IUPAC/Chemical Name

6,7-Bis(1-methylethyl)-2,4-pteridinediamine

InChi Key

LIVXWXAMTVJGCO-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H18N6/c1-5(2)7-8(6(3)4)16-11-9(15-7)10(13)17-12(14)18-11/h5-6H,1-4H3,(H4,13,14,16,17,18)

SMILES Code

NC1=NC(N)=C2N=C(C(C)C)C(C(C)C)=NC2=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 246.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Davies GAL, Wolfe LA, Mottola MF, MacKinnon C. N(o) 129-L'exercice physique pendant la grossesse et le postpartum. J Obstet Gynaecol Can. 2018 Feb;40(2):e66-e73. doi: 10.1016/j.jogc.2017.11.002. PubMed PMID: 29447727. 2: Amin AKMR, Tanaka M, Al-Saari N, Feng G, Mino S, Ogura Y, Hayashi T, Meirelles PM, Thompson FL, Gomez-Gil B, Sawabe T, Sawabe T. Thaumasiovibrio occultus gen. nov. sp. nov. and Thaumasiovibrio subtropicus sp. nov. within the family Vibrionaceae, isolated from coral reef seawater off Ishigaki Island, Japan. Syst Appl Microbiol. 2017 Jul;40(5):290-296. doi: 10.1016/j.syapm.2017.04.003. Epub 2017 Jun 16. Erratum in: Syst Appl Microbiol. 2018 Jan;41(1):62-63. PubMed PMID: 28648725. 3: Hofer E, Reis EM, Quintaes BR, Rodrigues DP, Feitosa IS, Angelo MR, Ribeiro LH. Vibrio cholerae resistant to 2,4-diamino-6,7-diisopropylpteridine (O/129) isolated from patients with enteritis in Ceará, Brazil. J Health Popul Nutr. 2001 Mar;19(1):39-42. PubMed PMID: 11394182. 4: Jain M, Kumar P, Goel AK. Emergence of Tetracycline Resistant Vibrio cholerae O1 Biotype El Tor Serotype Ogawa with Classical ctxB Gene from a Cholera Outbreak in Odisha, Eastern India. J Pathog. 2016;2016:1695410. doi: 10.1155/2016/1695410. Epub 2016 Jan 3. PubMed PMID: 26881083; PubMed Central PMCID: PMC4735907. 5: Gerbaud G, Dodin A, Goldstein F, Courvalin P. Genetic basis of trimethoprim and O/129 resistance in Vibrio cholerae. Ann Inst Pasteur Microbiol (1985). 1985 Nov-Dec;136B(3):265-73. PubMed PMID: 3008635. 6: Meng YC, Liu HC, Zhou YG, Cai M, Kang Y. Vibrio gangliei sp. nov., a novel member of Vibrionaceae isolated from sawdust in a pigpen. Int J Syst Evol Microbiol. 2018 Jun;68(6):1969-1974. doi: 10.1099/ijsem.0.002779. Epub 2018 Apr 20. PubMed PMID: 29676719. 7: Funke G, Lawson PA, Bernard KA, Collins MD. Most Corynebacterium xerosis strains identified in the routine clinical laboratory correspond to Corynebacterium amycolatum. J Clin Microbiol. 1996 May;34(5):1124-8. PubMed PMID: 8727888; PubMed Central PMCID: PMC228967. 8: Abbott SL, Cheung WK, Portoni BA, Janda JM. Isolation of vibriostatic agent O/129-resistant Vibrio cholerae non-O1 from a patient with gastroenteritis. J Clin Microbiol. 1992 Jun;30(6):1598-9. PubMed PMID: 1624583; PubMed Central PMCID: PMC265340. 9: Huq A, Alam M, Parveen S, Colwell RR. Occurrence of resistance to vibriostatic compound 0/129 in Vibrio cholerae 01 isolated from clinical and environmental samples in Bangladesh. J Clin Microbiol. 1992 Jan;30(1):219-21. PubMed PMID: 1734056; PubMed Central PMCID: PMC265025. 10: Iwamoto Y, Suzuki Y, Kurita A, Watanabe Y, Shimizu T, Ohgami H, Yanagihara Y. Vibrio trachuri sp. nov., a new species isolated from diseased Japanese horse mackerel. Microbiol Immunol. 1995;39(11):831-37. PubMed PMID: 8657009. 11: Matsushita S, Kudoh Y, Ohashi M. Transferable resistance to the vibriostatic agent 2,4-diamino-6,7-diisopropyl-pteridine (O/129) in Vibrio cholerae. Microbiol Immunol. 1984;28(10):1159-62. PubMed PMID: 6394970. 12: González-Castillo A, Enciso-Ibarrra J, Bolán-Mejia MC, Balboa S, Lasa A, Romalde JL, Cabanillas-Beltrán H, Gomez-Gil B. Vibrio mexicanus sp. nov., isolated from a cultured oyster Crassostrea corteziensis. Antonie Van Leeuwenhoek. 2015 Aug;108(2):355-64. doi: 10.1007/s10482-015-0488-1. Epub 2015 May 29. PubMed PMID: 26021481. 13: Wright DD, Brown SN. Nonclassical oxygen atom transfer as a synthetic strategy: preparation of an oxorhenium(V) complex of the bis(3,5-di-tert-butyl-2-phenoxo)amide ligand. Inorg Chem. 2013 Jul 15;52(14):7831-3. doi: 10.1021/ic4010592. Epub 2013 Jul 1. PubMed PMID: 23815641. 14: Wang Y, Leung PC, Qian PY, Gu JD. Antibiotic resistance and plasmid profile of environmental isolates of Vibrio species from Mai Po Nature Reserve, Hong Kong. Ecotoxicology. 2006 May;15(4):371-8. Epub 2006 May 6. PubMed PMID: 16680524. 15: Chen G, Hutter KJ, Zeller WJ. Positive correlation between cellular glutathione and acquired cisplatin resistance in human ovarian cancer cells. Cell Biol Toxicol. 1995 Oct;11(5):273-81. Erratum in: Cell Biol Toxicol 1996 Jun;12(3):187. PubMed PMID: 8608408. 16: Bouvet P, Chatelain R, Riou JY. [Value of the vibriostatic compound O/129 for the differentiation of the genera Staphylococcus and Micrococcus]. Ann Microbiol (Paris). 1982 Nov-Dec;133(3):449-53. French. PubMed PMID: 7165216. 17: Wang Y, Gu JD. Influence of temperature, salinity and pH on the growth of environmental Aeromonas and Vibrio species isolated from Mai Po and the Inner Deep Bay Nature Reserve Ramsar Site of Hong Kong. J Basic Microbiol. 2005;45(1):83-93. PubMed PMID: 15678554. 18: Pett VB, Haynes LW. 2,5-dichloro-2,5-dihydrothiophene 1-oxide: determination of the complete stereochemistry. Acta Crystallogr C. 2005 Apr;61(Pt 4):o211-2. Epub 2005 Mar 11. PubMed PMID: 15805630. 19: Khamala JK, Mwarumba S, Lewa P, Lowe B. Vibrio cholerae 01 strain resistant to vibriostatic compound 0/129 isolated from cholera cases in Kilifi, Kenya. East Afr Med J. 2002 Oct;79(10):560. PubMed PMID: 12635766. 20: Islam MS, Jahid MI, Rahman MM, Rahman MZ, Islam MS, Kabir MS, Sack DA, Schoolnik GK. Biofilm acts as a microenvironment for plankton-associated Vibrio cholerae in the aquatic environment of Bangladesh. Microbiol Immunol. 2007;51(4):369-79. PubMed PMID: 17446676.