GAT2711 is an α9* nAChR agonist. GAT2711 demonstrated a 230 nM potency as a full agonist at α9 nAChRs, being 340-fold selective over α7. GAT2711 inhibited ATP-induced interleukin-1β release in THP-1 cells. The analgesic activity of GAT2711 was fully retained in α7 knockout mice, suggesting that analgesic effects were potentially mediated through α9* nAChRs.
MedKoo Cat#: 126997
Name: GAT2711
CAS#: N/A
Chemical Formula: C20H27IN4O
Exact Mass: 466.1230
Molecular Weight: 466.37
Elemental Analysis: C, 51.51; H, 5.84; I, 27.21; N, 12.01; O, 3.43
The following data is based on the product molecular weight 466.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
