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MedKoo Cat#: 596382 | Name: Isoniazid pyruvate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoniazid pyruvate is a metabolite of isoniazid. Isoniazid (Laniazid, Nydrazid), also known as isonicotinylhydrazine (INH), is an organic compound that is the first-line medication in prevention and treatment of tuberculosis.

Chemical Structure

Isoniazid pyruvate
Isoniazid pyruvate
CAS#1081-50-1

Theoretical Analysis

MedKoo Cat#: 596382

Name: Isoniazid pyruvate

CAS#: 1081-50-1

Chemical Formula: C9H9N3O3

Exact Mass: 207.0644

Molecular Weight: 207.18

Elemental Analysis: C, 52.17; H, 4.38; N, 20.28; O, 23.17

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Isoniazid pyruvate; BRN 0185611; NSC 97221; NSC-97221; NSC97221; L 1011; Isonicotinoylhydrazonopyruvic acid;
IUPAC/Chemical Name
(E)-2-(2-isonicotinoylhydrazono)propanoic acid
InChi Key
ZGGPNDKKJIWQJU-IZZDOVSWSA-N
InChi Code
InChI=1S/C9H9N3O3/c1-6(9(14)15)11-12-8(13)7-2-4-10-5-3-7/h2-5H,1H3,(H,12,13)(H,14,15)/b11-6+
SMILES Code
O=C(C1=CC=NC=C1)N/N=C(C(O)=O)\C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 207.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Synthesis, characterisation and antitubercular activities of a series of pyruvate-containing aroylhydrazones and their Cu-complexes. Dalton Trans. 2012 Aug 14;41(30):9192-201. doi: 10.1039/c2dt30322a. Epub 2012 Jun 21. PubMed PMID: 22717728. 8: Shingnapurkar D, Dandawate P, Anson CE, Powell AK, Afrasiabi Z, Sinn E, Pandit S, Venkateswara Swamy K, Franzblau S, Padhye S. Synthesis and characterization of pyruvate-isoniazid analogs and their copper complexes as potential ICL inhibitors. Bioorg Med Chem Lett. 2012 May 1;22(9):3172-6. doi: 10.1016/j.bmcl.2012.03.047. Epub 2012 Mar 16. PubMed PMID: 22475559. 9: Rao ChV, Rawat AK, Singh AP, Singh A, Verma N. Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia (L.) Mill roots against antitubercular drugs induced hepatotoxicity in experimental models. Asian Pac J Trop Med. 2012 Apr;5(4):283-8. doi: 10.1016/S1995-7645(12)60040-6. PubMed PMID: 22449519. 10: Preziosi P. Isoniazid: metabolic aspects and toxicological correlates. Curr Drug Metab. 2007 Dec;8(8):839-51. Review. PubMed PMID: 18220565. 11: Romero B, Aranaz A, Bezos J, Alvarez J, de Juan L, Tariq Javed M, Mateos A, Gómez-Mampaso E, Domínguez L. Drug susceptibility of Spanish Mycobacterium tuberculosis complex isolates from animals. Tuberculosis (Edinb). 2007 Nov;87(6):565-71. Epub 2007 Sep 27. PubMed PMID: 17900988. 12: Xu J, Purcell WM. Energy metabolism and biotransformation as endpoints to pre-screen hepatotoxicity using a liver spheroid model. Toxicol Appl Pharmacol. 2006 Oct 15;216(2):293-302. Epub 2006 May 27. PubMed PMID: 16828827. 13: Rana SV, Pal R, Vaiphie K, Singh K. Effect of different oral doses of isoniazid-rifampicin in rats. Mol Cell Biochem. 2006 Sep;289(1-2):39-47. Epub 2006 Apr 1. PubMed PMID: 16583132. 14: Netopilová M, Haugvicová R, Kubová H, Drsata J, Mares P. Influence of convulsants on rat brain activities of alanine aminotransferase and aspartate aminotransferase. Neurochem Res. 2001 Dec;26(12):1285-91. PubMed PMID: 11885779. 15: Deol P, Khuller GK. Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice. Biochim Biophys Acta. 1997 Mar 15;1334(2-3):161-72. PubMed PMID: 9101710. 16: Shibata K, Marugami M, Kondo T. In vivo inhibition of kynurenine aminotransferase activity by isonicotinic acid hydrazide in rats. Biosci Biotechnol Biochem. 1996 May;60(5):874-6. PubMed PMID: 8704317. 17: Chugh Y, Agarwal AK, Sankaranarayanan A, Sharma PL. Effect of subacute DDT on pharmacokinetics of isoniazid and liver function in rabbits. Indian J Exp Biol. 1990 Sep;28(9):842-4. PubMed PMID: 2279776. 18: Feuer G, Balazs T, Farber TM, Ilse RG. Effect of cefazolin on aminotransferase activity in the rat. J Toxicol Environ Health. 1981 Mar-Apr;7(3-4):593-606. PubMed PMID: 7288905. 19: Wright JM, Timbrell JA. Factors affecting the metabolism of [14C]acetylhydrazine in rats. Drug Metab Dispos. 1978 Sep-Oct;6(5):561-6. 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