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MedKoo Cat#: 341559 | Name: Bunolol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bunolol hydrochloride is a biochemical.

Chemical Structure

Bunolol hydrochloride
Bunolol hydrochloride
CAS#31969-05-8

Theoretical Analysis

MedKoo Cat#: 341559

Name: Bunolol hydrochloride

CAS#: 31969-05-8

Chemical Formula: C17H26ClNO3

Exact Mass: 327.1601

Molecular Weight: 327.85

Elemental Analysis: C, 62.28; H, 7.99; Cl, 10.81; N, 4.27; O, 14.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Bunolol hydrochloride; W 6412A; W-6412A; W6412A; CCRIS 1062.
IUPAC/Chemical Name
(+-)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-3,4-dihydro-1(2H)-naphthalenone hydrochloride
InChi Key
DNTDOBSIBZKFCP-YDALLXLXSA-N
InChi Code
InChI=1S/C17H25NO3.ClH/c1-17(2,3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20;/h5-6,9,12,18-19H,4,7-8,10-11H2,1-3H3;1H/t12-;/m0./s1
SMILES Code
C1CC(=O)c2c(c(OC[C@@H](O)CNC(C)(C)C)ccc2)C1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 327.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Argikar UA, Dumouchel JL, Dunne CE, Saran C, Cirello AL, Gunduz M. Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways. Drug Metab Dispos. 2016 Aug;44(8):1304-12. doi: 10.1124/dmd.116.070458. Epub 2016 May 17. PubMed PMID: 27190057. 2: Horcajada-Reales C, Rodríguez-Soria VJ, Suárez-Fernández R. Allergic contact dermatitis caused by timolol with cross-sensitivity to levobunolol. Contact Dermatitis. 2015 Dec;73(6):368-9. doi: 10.1111/cod.12448. Epub 2015 Jul 31. PubMed PMID: 26227808. 3: Kochar B, Shan SJ, Anand G, Zinreich SJ, Gelber AC. Totally one-sided: painless unilateral proptosis. Am J Med. 2015 Apr;128(4):361-3. doi: 10.1016/j.amjmed.2014.12.005. Epub 2015 Jan 5. PubMed PMID: 25572713. 4: Lin L, Wang Y, Chen Y, Liu M. Bradyarrhythmias secondary to topical levobunolol hydrochloride solution. Clin Interv Aging. 2014 Oct 13;9:1741-5. doi: 10.2147/CIA.S69420. eCollection 2014. PubMed PMID: 25342892; PubMed Central PMCID: PMC4206249. 5: Choi H, Lee Y, Yeon S, Lee H, Lee H. Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs. J Vet Sci. 2011 Mar;12(1):99-101. PubMed PMID: 21368570; PubMed Central PMCID: PMC3053475. 6: Scardillo A, Pugliese M, De Majo M, Niutta PP, Pugliese A. Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma. Vet Ther. 2010 Fall;11(3):E1-6. PubMed PMID: 20960417. 7: Pugliese M, Scardillo A, Niutta PP, Pugliese A. Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs. Vet Res Commun. 2009 Sep;33 Suppl 1:205-7. doi: 10.1007/s11259-009-9273-9. PubMed PMID: 19626454. 8: Karataş A, Sonakin O, Kiliçarslan M, Baykara T. Poly (epsilon-caprolactone) microparticles containing Levobunolol HCl prepared by a multiple emulsion (W/O/W) solvent evaporation technique: effects of some formulation parameters on microparticle characteristics. J Microencapsul. 2009 Feb;26(1):63-74. doi: 10.1080/02652040802141039. PubMed PMID: 18608798. 9: Ciancaglini M, Carpineto P, Agnifili L, Nubile M, Fasanella V, Lanzini M, Calienno R, Mastropasqua L. An in vivo confocal microscopy and impression cytology analysis of preserved and unpreserved levobunolol-induced conjunctival changes. Eur J Ophthalmol. 2008 May-Jun;18(3):400-7. PubMed PMID: 18465723. 10: Ramadan NK, Zaazaa HE. Membrane electrodes for determination of some beta-blocker drugs. J AOAC Int. 2007 Jul-Aug;90(4):987-94. PubMed PMID: 17760336. 11: Dong Y, Ishikawa H, Wu Y, Yoshitomi T. Vasodilatory mechanism of levobunolol on vascular smooth muscle cells. Exp Eye Res. 2007 Jun;84(6):1039-46. Epub 2007 Jan 27. PubMed PMID: 17459374. 12: Wu KY, Wang HZ, Hong SJ. Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells. Kaohsiung J Med Sci. 2007 Mar;23(3):105-11. PubMed PMID: 17389174. 13: Blumetti B, Brodell RT, Helms SE, Brodell LP, Bredle DL. Contact dermatitis to levobunolol eyedrops superimposed on IgE-mediated rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2006 Dec;97(6):817-8. PubMed PMID: 17201244. 14: Nino M, Balato A, Ayala F, Balato N. Allergic contact dermatitis due to levobunolol with cross-sensitivity to befunolol. Contact Dermatitis. 2007 Jan;56(1):53-4. PubMed PMID: 17177718. 15: Spratt A, Ogunbowale L, Khawaja A, Franks W. Drops and falls. Age Ageing. 2006 Nov;35(6):646. PubMed PMID: 17047012. 16: Hashimoto Y, Aragane Y, Kawada A. Allergic contact dermatitis due to levobunolol in an ophthalmic preparation. J Dermatol. 2006 Jul;33(7):507-9. PubMed PMID: 16848829. 17: Beta-blocker eye drops. Nurs Times. 2006 May 30-Jun 5;102(22):29. PubMed PMID: 16764382. 18: Wu KY, Hong SJ, Wang HZ. Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells. Kaohsiung J Med Sci. 2006 Feb;22(2):60-7. PubMed PMID: 16568722. 19: Inoue K, Ezure T, Wakakura M, Inoue J, Tomita G. The effect of once-daily levobunolol on intraocular pressure in normal-tension glaucoma. Jpn J Ophthalmol. 2005 Jan-Feb;49(1):58-9. PubMed PMID: 15692777. 20: Tan JC, Hitchings RA. Reversal of disc cupping after intraocular pressure reduction in topographic image series. J Glaucoma. 2004 Oct;13(5):351-5. PubMed PMID: 15354070.