Synonym
Adn 138; Adn-138; Adn138
IUPAC/Chemical Name
Spiro(pyrrolidine-3,6'(5'H)-pyrrolo(1,2,3-de)(1,4)benzoxazine)-2,5,5'-trione, 8'-chloro-2',3'-dihydro-
InChi Key
WSLOHMLGIVSUPR-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H9ClN2O4/c14-6-3-7-10-8(4-6)20-2-1-16(10)12(19)13(7)5-9(17)15-11(13)18/h3-4H,1-2,5H2,(H,15,17,18)
SMILES Code
O=C(C1(C2=C3N(C1=O)CCOC3=CC(Cl)=C2)C4)NC4=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
292.68
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Wrobel J, Dietrich A, Woolson SA, Millen J, McCaleb M, Harrison MC, Hohman TC, Sredy J, Sullivan D. Novel spirosuccinimides with incorporated isoindolone and benzisothiazole 1,1-dioxide moieties as aldose reductase inhibitors and antihyperglycemic agents. J Med Chem. 1992 Nov 27;35(24):4613-27. PubMed PMID: 1469692.
2: Hirata Y, Okada K. Relation of Na+, K(+)-ATPase to delayed motor nerve conduction velocity: effect of aldose reductase inhibitor, ADN-138, on Na+, K(+)-ATPase activity. Metabolism. 1990 Jun;39(6):563-7. PubMed PMID: 2161992.
3: Akagi Y, Ikebe H, Terubayashi H, Takahashi Y, Tsuji T. [Morphological classification of the prevention by aldose reductase inhibitor of rat galactosemic cataract]. Nippon Ganka Gakkai Zasshi. 1989 Apr;93(4):494-500. Japanese. PubMed PMID: 2508449.
4: Segawa M, Hirata Y, Fujimori S, Okada K. The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia. Metabolism. 1988 May;37(5):454-60. PubMed PMID: 3285132.
5: Hirata Y, Fujimori S, Okada K. Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats. Metabolism. 1988 Feb;37(2):159-63. PubMed PMID: 2828821.
