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MedKoo Cat#: 591167 | Name: Drofenine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Drofenin is an anticonvulsant. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers (neurotropic musculotropic effect). Drofenin also acts as FIASMA (functional inhibitor of acid sphingomyelinase )

Chemical Structure

Drofenine
Drofenine
CAS#1679-76-1 (free base)

Theoretical Analysis

MedKoo Cat#: 591167

Name: Drofenine

CAS#: 1679-76-1 (free base)

Chemical Formula: C20H31NO2

Exact Mass: 317.2355

Molecular Weight: 317.47

Elemental Analysis: C, 75.67; H, 9.84; N, 4.41; O, 10.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1679-76-1 (free base) 548-66-3 (HCl)
Synonym
Drofenine; Cycloadiphene; Drofenina; Cycloadiphenine; Adiphenine H; NSC757809; NSC 757809; NSC-757809;
IUPAC/Chemical Name
2-(Diethylamino)ethyl alpha-phenylcyclohexaneacetate
InChi Key
AGJBLWCLQCKRJP-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H31NO2/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18/h5,7-8,11-12,18-19H,3-4,6,9-10,13-16H2,1-2H3
SMILES Code
O=C(OCCN(CC)CC)C(C1=CC=CC=C1)C2CCCCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 317.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Deering-Rice CE, Mitchell VK, Romero EG, Abdel Aziz MH, Ryskamp DA, Križaj D, Gopal VR, Reilly CA. Drofenine: A 2-APB Analogue with Greater Selectivity for Human TRPV3. Pharmacol Res Perspect. 2014 Oct;2(5):e00062. PubMed PMID: 25089200; PubMed Central PMCID: PMC4115637. 2: Bodur E, Cokuğraş AN, Tezcan EF. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-9. PubMed PMID: 11360997. 3: Kunysz EL, Michel AD, Whiting RL. Functional and direct binding studies using subtype selective muscarinic receptor antagonists. Br J Pharmacol. 1988 Mar;93(3):491-500. PubMed PMID: 2897216; PubMed Central PMCID: PMC1853838. 4: Facchini G, Zaccheo F, Nannetti M. Simultaneous determination of hydrochloride salts of adiphenine, diphenhydramine, ethyldiphenacetate, drofenine and promazine by ion-pair HPLC. Boll Chim Farm. 1983 Aug;122(8):405-11. PubMed PMID: 6140928. 5: Pawelczyk E, Hermann T, Marciniec B, Pluta I. Studies on kinetics of degradation of drugs. XIX. Thermic degradation of aminophenazone (AP), allobarbital (AB), cycloadiphenine hydrochloride (CAD) mixture in cetyl phtalate medium. Acta Pol Pharm. 1971;28(6):594-602. PubMed PMID: 5163824.