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MedKoo Cat#: 558052 | Name: Mauritianin
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mauritianin is a flavonoid glycoside that has been found in R. anguifera and is a DNA topoisomerase I inhibitor. It stabilizes the covalent complex between DNA and recombinant human topoisomerase I when used at a concentration of 100 µM.

Chemical Structure

Mauritianin
Mauritianin
CAS#109008-28-8

Theoretical Analysis

MedKoo Cat#: 558052

Name: Mauritianin

CAS#: 109008-28-8

Chemical Formula: C33H40O19

Exact Mass: 740.2164

Molecular Weight: 740.66

Elemental Analysis: C, 53.51; H, 5.44; O, 41.04

Price and Availability

Size Price Availability Quantity
1mg USD 270.00 2 Weeks
5mg USD 700.00 2 Weeks
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Related CAS #
No Data
Synonym
Mauritianin;
IUPAC/Chemical Name
5,7-dihydroxy-3-(((2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChi Key
AEOBNVBHRFQADS-DNDPRTLXSA-N
InChi Code
1S/C33H40O19/c1-10-19(38)23(42)25(44)31(46-10)50-28-21(40)17(9-34)49-33(30(28)52-32-26(45)24(43)20(39)11(2)47-32)51-29-22(41)18-15(37)7-14(36)8-16(18)48-27(29)12-3-5-13(35)6-4-12/h3-8,10-11,17,19-21,23-26,28,30-40,42-45H,9H2,1-2H3/t10-,11-,17+,19-,20-,21-,23+,24+,25+,26+,28-,30+,31-,32-,33+/m0/s1
SMILES Code
C[C@@H]1O[C@@H](O[C@H]2[C@@H](O)[C@@H](CO)O[C@H](OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)cc5)[C@@H]2O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)[C@H](O)[C@H](O)[C@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Mauritianin is a topoisomerase I inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 100.0 135.01
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 740.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Krasteva I, Bratkov V, Bucar F, Kunert O, Kollroser M, Kondeva-Burdina M, Ionkova I. Flavoalkaloids and Flavonoids from Astragalus monspessulanus. J Nat Prod. 2015 Nov 25;78(11):2565-71. doi: 10.1021/acs.jnatprod.5b00502. Epub 2015 Nov 11. PubMed PMID: 26558405. 2: Wang LQ, Tang ZR, Mu WH, Kou JF, He DY. A new natural naphtho[1,2-b]furan from the leaves of Cassia fistula. J Asian Nat Prod Res. 2013 Nov;15(11):1210-3. doi: 10.1080/10286020.2013.812077. Epub 2013 Jul 4. PubMed PMID: 23822190. 3: de Araújo MF, Curcino Vieira IJ, Sant'Anna CM, da Silva DR, Vitorino Maia AI, Braz-Filho R, Vieira-da-Motta O, Mathias L. New triterpene glycoside and other chemical constituents from the leaves of Swartzia apetala Raddi var. glabra. Nat Prod Res. 2013 Oct;27(20):1888-95. doi: 10.1080/14786419.2013.782493. Epub 2013 Mar 28. PubMed PMID: 23537160. 4: Kicel A, Wolbiś M. Study on the phenolic constituents of the flowers and leaves of Trifolium repens L. Nat Prod Res. 2012 Nov;26(21):2050-4. Epub 2011 Nov 25. PubMed PMID: 22117193. 5: Lu Z, Zhang Q, Chen R, Yu D. [Study on chemical constituents from branches and leaves of Polyalthia nemoralis]. Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(8):1024-7. Chinese. PubMed PMID: 21809577. 6: Zhao Q, Li C, Yang J, Zhang D. [Chemical constituents of Clausena lansium]. Zhongguo Zhong Yao Za Zhi. 2010 Apr;35(8):997-1000. Chinese. PubMed PMID: 20617679. 7: Shoji K, Miki N, Nakajima N, Momonoi K, Kato C, Yoshida K. Perianth bottom-specific blue color development in Tulip cv. Murasakizuisho requires ferric ions. Plant Cell Physiol. 2007 Feb;48(2):243-51. Epub 2006 Dec 19. Erratum in: Plant Cell Physiol. 2007 Jul;48(7):1079. PubMed PMID: 17179184. 8: Nahrstedt A, Hungeling M, Petereit F. Flavonoids from Acalypha indica. Fitoterapia. 2006 Sep;77(6):484-6. Epub 2006 May 24. PubMed PMID: 16828241. 9: Ma J, Jones SH, Marshall R, Wu X, Hecht SM. DNA topoisomerase I inhibitors from Rinorea anguifera. Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6. PubMed PMID: 15664863. 10: Yasukawa K, Takido M, Takeuchi M, Sato Y, Nitta K, Nakagawa S. Inhibitory effects of flavonol glycosides on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Chem Pharm Bull (Tokyo). 1990 Mar;38(3):774-6. PubMed PMID: 2112048. 11: De Simone F, Dini A, Pizza C, Saturnino P, Schettino O. Two flavonol glycosides from Chenopodium quinoa. Phytochemistry. 1990;29(11):3690-2. PubMed PMID: 1367265.

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Maysin

Maysin