MedKoo Cat#: 596235 | Name: Dihexyverine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dihexyverine HCl is an antimuscarinic with effects similar to those of atropine. it has been given in the symptomatic treatment of gastrointestinal spasm.

Chemical Structure

Dihexyverine HCl
CAS#5588-25-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 596235

Name: Dihexyverine HCl

CAS#: 5588-25-0 (HCl)

Chemical Formula: C20H36ClNO2

Exact Mass: 357.2435

Molecular Weight: 357.96

Elemental Analysis: CC, 67.11; H, 10.14; Cl, 9.90; N, 3.91; O, 8.94

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Synonym
Dihexyverine HCl; Diverine; Dihexyverine hydrochloride; Neospasmina; Olimplex; Seclin; Spasmodex; JL 1078;
IUPAC/Chemical Name
2-(piperidin-1-yl)ethyl [1,1'-bi(cyclohexane)]-1-carboxylate hydrochloride
InChi Key
AQFATCCHOXBYNK-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H35NO2.ClH/c22-19(23-17-16-21-14-8-3-9-15-21)20(12-6-2-7-13-20)18-10-4-1-5-11-18;/h18H,1-17H2;1H
SMILES Code
O=C(C1(C2CCCCC2)CCCCC1)OCCN3CCCCC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: BUCHEL L, LIBLAU L. [MECHANISM OF THE PHENOMENA OF SYNERGISM OF EXPERIMENTAL SLEEP. I. STUDY OF THE ASSOCIATIONS CHLORPROMAZINE-HEXOBARBITOL, DIHEXYVERINE-HEXOBARBITAL, IN MICE]. Arch Sci Physiol (Paris). 1964;18:339-61. French. PubMed PMID: 14251293. 2: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Can Med Assoc J. 1962 Nov 24;87:1121-3. French. PubMed PMID: 13944939; PubMed Central PMCID: PMC1849825. 3: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Union Med Can. 1962 Aug;91:832-6. French. PubMed PMID: 13892604. 4: DELECOUR, VITSE, MONNIER. [Clinical experimentation with an antispasmodic, "Dihexyverine", in obstetrical practice]. Lille Med. 1962 Feb;7:143-6. French. PubMed PMID: 13885120. 5: BILWEIS J. [Experimental study on the use of dihexyverine in obstetrical labor by the physiological accelerated labor method]. Concours Med. 1958 Mar 8;80(10):1193-5. French. PubMed PMID: 13511938. 6: MEUNIER H. [Use of dihexyverine in gynecology]. Gaz Med Fr. 1957 Sep 25;64(18):1533-4. French. PubMed PMID: 13480436. 7: ROLLIN G. [Trial therapy of spastic cough with a new synthetic antispasmodic: dihexyverine]. Gaz Med Fr. 1955 Dec 25;62(24):1962-3. French. PubMed PMID: 13294387. 8: FRANCK C, LAMARCHE M, ROZE P. [Modifications in the resistance to oxygen deficiency in the guinea pig after administration of dihexyverine]. C R Seances Soc Biol Fil. 1955 Dec;149(23-24):2201-2. French. PubMed PMID: 13317334. 9: SIMON C, CARRAUD G. [Contribution to the treatment of enteropathies; digestive application of a new synthetic spasmolytic--dihexyverine]. Sem Hop. 1955 Mar 20;31(18/2):91-3. French. PubMed PMID: 14373023. 10: FRANCK C, GRANDPIERRE R. [Effect of dihexyverine on histaminic bronchospasm in guinea pigs]. Rev Pathol Gen Physiol Clin. 1955 Mar;55(666):387-9. French. PubMed PMID: 14396051. 11: LE BARS H, MAGNE J. [Pharmacodynamic study of [bicyclohexyl]-1-carboxylic acid 2-piperidino-ethyl ester hydrochloride (dihexyverine)]. Therapie. 1955;10(3):514-25. French. PubMed PMID: 13299206.