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MedKoo Cat#: 596200 | Name: Vinylbital

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vinylbital, also known as butylvinal, is a sedative hypnotic drug which is a barbiturate derivative. It was developed by Aktieboleget Pharmacia in the 1950s. Vinylbital is discontinued.

Chemical Structure

Vinylbital
Vinylbital
CAS#2430-49-1

Theoretical Analysis

MedKoo Cat#: 596200

Name: Vinylbital

CAS#: 2430-49-1

Chemical Formula: C11H16N2O3

Exact Mass: 224.1161

Molecular Weight: 224.26

Elemental Analysis: C, 58.91; H, 7.19; N, 12.49; O, 21.40

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
Vinylbital; JD-96; Bykonox; butylvinal; Speda; Vinylbitone;
IUPAC/Chemical Name
5-(pentan-2-yl)-5-vinylpyrimidine-2,4,6(1H,3H,5H)-trione
InChi Key
KGKJZEKQJQQOTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16N2O3/c1-4-6-7(3)11(5-2)8(14)12-10(16)13-9(11)15/h5,7H,2,4,6H2,1,3H3,(H2,12,13,14,15,16)
SMILES Code
O=C1NC(C(C(C)CCC)(C=C)C(N1)=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 224.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Maurer HH. Identification and differentiation of barbiturates, other sedative-hypnotics and their metabolites in urine integrated in a general screening procedure using computerized gas chromatography-mass spectrometry. J Chromatogr. 1990 Sep 14;530(2):307-26. PubMed PMID: 2079506. 2: De Groot G, Maes RA, Van Heijst AN. A toxicological evaluation of different adsorbents in hemoperfusion. Clin Toxicol. 1981 Oct;18(10):1199-211. PubMed PMID: 6122529. 3: Vermeulen NP, Bakker BH, Eylers D, Breimer DD. The epoxide-diol pathway in the metabolism of vinylbital in rat and man. Xenobiotica. 1980 Mar;10(3):159-68. PubMed PMID: 6110286. 4: Preuss FR, Gutzler H. [Studies on the biotransformation of 5-vinyl-5-(1-methylbutyl)- and 5-vinyl-5-(1-ethyl-propyl)-barbituric acid (author's transl)]. Arzneimittelforschung. 1976;26(11):2080-4. German. PubMed PMID: 1037252. 5: Breimer DD, de Boer AG. Pharmacokinetics and relative bioavailability of vinylbital in man after oral and rectal administration. Arzneimittelforschung. 1976;26(3):448-54. PubMed PMID: 989344. 6: Geldmacher-von Mallinck, Egger B. [Metabolism of 5-vinyl-5-(1'-methylbutyl)-barbituric acid (vinylbital) in man. 3. Metabolism and excretion of (-)-vinylbital]. Arzneimittelforschung. 1971 Aug;21(8):1272-4. German. PubMed PMID: 5110033. 7: Geldmacher-von Mallinck, Egger B, Fröhlich F. [Metabolism of 5-vinyl-5-(1'-methylbutyl)-barbituric acid (Vinylbital) in human. 2. Course of metabolite elimination of racemic vinylbital in urine]. Arzneimittelforschung. 1971 Jul;21(7):939-41. German. PubMed PMID: 5109505. 8: Knabe J, Geismar W. [Barbituric acid derivatives. 4. Relative configuration of opt. active pentobarbital, vinylbital and thiopental]. Arch Pharm Ber Dtsch Pharm Ges. 1968 Sep;301(9):682-5. German. PubMed PMID: 5250001. 9: Preuss FR, Müller D. [Studies on the biotransformation of 5-(1'-methyl-n-butyl)-5-vinylbarbituric acid (Vinylbital). 3. Isolation and identification of a renal excretion product and synthesis of some comparative substances]. Arzneimittelforschung. 1968 Jun;18(6):714-8. German. PubMed PMID: 5755809. 10: Preuss FR, Müller D. [Studies on the biotransformation of 5-(1'-methyl-n-butyl)-5-vinylbarbituric acid (Vinylbital). 2. Synthesis of some substances as possible degradatuon producrs of Vinylbital]. Arzneimittelforschung. 1968 May;18(5):606-10. German. PubMed PMID: 5755893. 11: Jovanović UJ. [Neurophysiologic interpretation of the mechanism of action of vinylbital]. Arzneimittelforschung. 1967 Nov;17(11):1369-74. Review. German. PubMed PMID: 4876966.

View History

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