MedKoo Cat#: 341360 | Name: Vintriptol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Vintriptol is a biochemical.

Chemical Structure

Vintriptol
Vintriptol
CAS#81600-06-8

Theoretical Analysis

MedKoo Cat#: 341360

Name: Vintriptol

CAS#: 81600-06-8

Chemical Formula: C56H68N6O9

Exact Mass: 968.5048

Molecular Weight: 969.19

Elemental Analysis: C, 69.40; H, 7.07; N, 8.67; O, 14.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Vintriptol; Vintriptolum.
IUPAC/Chemical Name
Vincaleukoblastine, O(sup 4)-deacetyl-3-de(methoxycarbonyl)-3-(((2-ethoxy-1-(1H-indol-3-ylmethyl)-2-oxoethyl)amino)carbonyl)-, (23(S))-
InChi Key
CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O
InChi Code
CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O
SMILES Code
CC[C@@]1(C[C@H]2C[C@@](c3c(c4ccccc4[nH]3)CCN(C2)C1)(c5cc6c(cc5OC)N([C@@H]7[C@]68CCN9[C@H]8[C@@](C=CC9)([C@H]([C@@]7(C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)OCC)O)O)CC)C)C(=O)OC)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 969.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Damen CW, Rosing H, Tibben MM, van Maanen MJ, Lagas JS, Schinkel AH, Schellens JH, Beijnen JH. A sensitive assay for the quantitative analysis of vinorelbine in mouse and human EDTA plasma by high-performance liquid chromatography coupled with electrospray tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Jun 1;868(1-2):102-9. doi: 10.1016/j.jchromb.2008.04.046. Epub 2008 May 10. PubMed PMID: 18501686. 2: Budman DR. New vinca alkaloids and related compounds. Semin Oncol. 1992 Dec;19(6):639-45. Review. PubMed PMID: 1462165. 3: Boven E, Hendriks HR, Erkelens CA, Pinedo HM. The anti-tumour effects of the prodrugs N-l-leucyl-doxorubicin and vinblastine-isoleucinate in human ovarian cancer xenografts. Br J Cancer. 1992 Dec;66(6):1044-7. PubMed PMID: 1457343; PubMed Central PMCID: PMC1978011. 4: van Tellingen O, Beijnen JH, Baurain R, ten Bokkel Huinink WW, van der Woude HR, Nooyen WJ. Biodetermination of N-(deacetyl-O-4-vinblastoyl-23)-L-tryptophan, a metabolite of vintriptol, by high-performance liquid chromatography with fluorescence detection. J Chromatogr. 1992 Feb 14;574(2):293-8. PubMed PMID: 1618962. 5: Hendriks HR, Langdon S, Berger DP, Breistøl K, Fiebig HH, Fodstad O, Schwartsmann G. Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts. Eur J Cancer. 1992;28A(4-5):767-73. PubMed PMID: 1524896. 6: Oosterkamp HM, Vlasveld LT, Wanders J, Beijnen JH, van Tellingen O, Dubbelman AC, Simonetti GP, Franklin HR, Vermorken JB, Ten Bokkel Huinink WW. Phase I study of vintriptol, a tryptophan ester of vinblastine. Eur J Cancer. 1991;27(10):1222-6. PubMed PMID: 1835590. 7: van Tellingen O, van der Woude HR, Beijnen JH, Rao KS, ten Bokkel Huinink WW, Nooyen WJ. High-performance liquid chromatographic bio-analysis and preliminary pharmacokinetics of the experimental antitumour drug vintriptol. J Chromatogr. 1990 Aug 3;529(2):329-38. PubMed PMID: 2229252. 8: Ceulemans F, Humblet Y, Bosly A, Symann M, Trouet A. A phase I study of vinblastine tryptophan ester. Cancer Chemother Pharmacol. 1986;18(1):44-6. PubMed PMID: 3757158.