IUPAC/Chemical Name
3,5-dibutyl-6-(1-butyl-2-oxoheptyl)-4-hydroxy-2H-pyran-2-one
InChi Key
SNSPVFCYLPZTRZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H40O4/c1-5-9-13-17-21(25)18(14-10-6-2)23-19(15-11-7-3)22(26)20(16-12-8-4)24(27)28-23/h18,26H,5-17H2,1-4H3
SMILES Code
O=C1C(CCCC)=C(O)C(CCCC)=C(C(CCCC)C(CCCCC)=O)O1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
392.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cook L, Ternai B, Ghosh P. Inhibition of human sputum elastase by substituted 2-pyrones. J Med Chem. 1987 Jun;30(6):1017-23. PubMed PMID: 3647139.
2: Spencer RW, Copp LJ, Pfister JR. Inhibition of human leukocyte elastase, porcine pancreatic elastase, and chymotrypsin by elasnin and other 4-hydroxy-2-pyrones. J Med Chem. 1985 Dec;28(12):1828-32. PubMed PMID: 4068006.
3: Groutas WC, Stanga MA, Brubaker MJ, Huang TL, Moi MK, Carroll RT. Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases. J Med Chem. 1985 Aug;28(8):1106-9. PubMed PMID: 3848491.
4: Ohno H, Yoshida M, Takahashi Y, Omura S. Improvement of the productivity of elasnin, a specific elastase inhibitor, by Streptomyces noboritoensis KM-2753. J Antibiot (Tokyo). 1980 May;33(5):474-9. PubMed PMID: 6903571.
5: Ohno H, Saheki T, Awaya J, Nakagawa A, Omura S. Isolation and characterization of elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. J Antibiot (Tokyo). 1978 Nov;31(11):1116-23. PubMed PMID: 721707.
6: Omura S, Ohno H, Saheki T, Yoshida M, Nakagawa A. Elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. Biochem Biophys Res Commun. 1978 Jul 28;83(2):704-9. PubMed PMID: 697852.
