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MedKoo Cat#: 562790 | Name: MK6-83
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK6-83 is an agonist of the transient receptor potential channel ML3 (TRPML3).

Chemical Structure

MK6-83
MK6-83
CAS#1062271-24-2

Theoretical Analysis

MedKoo Cat#: 562790

Name: MK6-83

CAS#: 1062271-24-2

Chemical Formula: C16H20N2O2S2

Exact Mass: 336.0966

Molecular Weight: 336.47

Elemental Analysis: C, 57.12; H, 5.99; N, 8.33; O, 9.51; S, 19.06

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
MK6-83; MK6 83; MK683;
IUPAC/Chemical Name
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-Thiophenesulfonamide
InChi Key
IRGYSXZCDAWOOC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H20N2O2S2/c1-13-9-10-16(21-13)22(19,20)17-14-7-3-4-8-15(14)18-11-5-2-6-12-18/h3-4,7-10,17H,2,5-6,11-12H2,1H3
SMILES Code
O=S(C1=CC=C(C)S1)(NC2=CC=CC=C2N3CCCCC3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency.
In vitro activity:
Then, to assess the role of TRPML-1, cell viability assays have been conducted in T98 and U251 cell lines treated with the specific TRPML-1 agonist, MK6-83. This study found that MK6-83 reduced cell viability and induced caspase-3-dependent apoptosis. Reference: Cancers (Basel). 2019 Apr 12;11(4):525. https://pubmed.ncbi.nlm.nih.gov/31013784/
In vivo activity:
TBD
Solvent mg/mL mM comments
Solubility
DMF 30.0 89.16
DMSO 38.9 115.65
DMSO:PBS (pH 7.2) (1:2) 0.3 0.98
Ethanol 4.2 12.42
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 336.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G. Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival. Cancers (Basel). 2019 Apr 12;11(4):525. doi: 10.3390/cancers11040525. PMID: 31013784; PMCID: PMC6521337.
In vitro protocol:
Morelli MB, Amantini C, Tomassoni D, Nabissi M, Arcella A, Santoni G. Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival. Cancers (Basel). 2019 Apr 12;11(4):525. doi: 10.3390/cancers11040525. PMID: 31013784; PMCID: PMC6521337.
In vivo protocol:
TBD
1: Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C, Grimm C. A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat Commun. 2014 Aug 14;5:4681. doi: 10.1038/ncomms5681. PubMed PMID: 25119295.