MK-996, also known as L-159282, is a potent, orally active, highly selective, nonpeptide angiotensin II (AII) receptor antagonist. The duration of antihypertensive activity of MK-996 is similar to enalapril and shorter than losartan at the doses tested. Additionally, in the rat MK-996 does not potentiate the vasodepressor response to bradykinin and completely prevents the ability of AII to stimulate an increase in plasma levels of aldosterone. Therefore, MK-996 is a potent, orally active, nonpeptide AII receptor antagonist with a long duration of action, little species variability, and anti-hypertensive activity.
MedKoo Cat#: 525660
Name: MK-996
CAS#: 157263-00-8
Chemical Formula: C30H28N4O3S
Exact Mass: 524.1882
Molecular Weight: 524.63
Elemental Analysis: C, 68.68; H, 5.38; N, 10.68; O, 9.15; S, 6.11
The following data is based on the product molecular weight 524.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
