MK181 is an AKR1B10 inhibitor. MK181 can bind into the external loop A subpocket. AKR1B10 has evolved as a tumor marker and promising antineoplastic target. It shares high structural similarity with the diabetes target enzyme aldose reductase (AR).
MedKoo Cat#: 561246
Name: MK181
CAS#: 314297-32-0
Chemical Formula: C16H13BrClNO4
Exact Mass: 396.9716
Molecular Weight: 398.64
Elemental Analysis: C, 48.21; H, 3.29; Br, 20.04; Cl, 8.89; N, 3.51; O, 16.05
The following data is based on the product molecular weight 398.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
