Bermoprofen | CAS# 78499-27-1

MedKoo Cat#: 591058 | Name: Bermoprofen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bermoprofen is a bioactive chemical.

Chemical Structure

Bermoprofen

CAS#78499-27-1

Theoretical Analysis

MedKoo Cat#: 591058

Name: Bermoprofen

CAS#: 78499-27-1

Chemical Formula: C18H16O4

Exact Mass: 296.1049

Molecular Weight: 296.32

Elemental Analysis: C, 72.96; H, 5.44; O, 21.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Bermoprofen;

IUPAC/Chemical Name

Dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-alpha,8-dimethyl-11-oxo-

InChi Key

REHLODZXMGOGQP-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16O4/c1-10-3-5-16-13(7-10)9-15(19)14-8-12(11(2)18(20)21)4-6-17(14)22-16/h3-8,11H,9H2,1-2H3,(H,20,21)

SMILES Code

O=C(O)C(C)C1=CC=C(C2=C1)OC3=CC=C(C)C=C3CC2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 296.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mori M, Nakamura Y, Shirai Y, Seto Y, Nakamura H, Makita H, Imasato Y. Prolongation of antipyretic action and reduction of gastric ulcerogenicity in the rat by controlled-release granules of bermoprofen, a new nonsteroidal anti-inflammatory drug. J Pharm Sci. 1991 Sep;80(9):876-80. PubMed PMID: 1800712. 2: Ishii K, Nakamura H, Yokoyama Y, Motoyoshi S, Kadokawa T. [Mode of anti-inflammatory action of a non-steroidal anti-inflammatory drug, AD-1590]. Yakugaku Zasshi. 1988 Oct;108(10):1001-7. Japanese. PubMed PMID: 3073207. 3: Hino K, Nakamura H, Kato S, Irie A, Nagai Y, Uno H. Nonsteroidal antiinflammatory agents. III. Synthesis of the metabolites of 10,11-dihydro-8, alpha-dimethyl-11-oxodibenz-[b,f]oxepin-2-acetic acid (bermoprofen). Chem Pharm Bull (Tokyo). 1988 Sep;36(9):3462-7. PubMed PMID: 3240540. 4: Nakamura H, Motoyoshi S, Seto Y, Kadokawa T. [Anti-inflammatory, analgesic, antipyretic and gastrointestinal ulcerogenic activities of metabolites of bermoprofen (AD-1590), a non-steroidal anti-inflammatory agent]. Yakugaku Zasshi. 1988 Aug;108(8):788-93. Japanese. PubMed PMID: 3266759. 5: Nakamura H, Motoyoshi S, Ishii K, Kadokawa T. [Inhibitory effect of AD-1590, a non-steroidal anti-inflammatory drug, on allergic inflammation in mice and rats]. Nihon Yakurigaku Zasshi. 1988 Jul;92(1):29-38. Japanese. PubMed PMID: 3265405. 6: Nakamura H, Seto Y, Motoyoshi S, Yokoyama Y, Kadokawa T. [A correlation between the species differences in anti-inflammatory activity of AD-1590, a non-steroidal anti-inflammatory drug, and its plasma level]. Nihon Yakurigaku Zasshi. 1988 Jun;91(6):393-9. Japanese. PubMed PMID: 3138169. 7: Takahashi T, Mori M, Uezono Y, Makita H, Nakanishi Y, Imasato Y. Suitable size of preparations to evaluate the bioavailability of enteric-coated preparations by the use of gastric-acidity-controlled rabbits. Chem Pharm Bull (Tokyo). 1986 Nov;34(11):4738-43. PubMed PMID: 3829190. 8: Takahashi T, Kagami I, Kitamura K, Nakanishi Y, Imasato Y. Stabilization of AD-1590, a non-steroidal antiinflammatory agent, in suppository bases by beta-cyclodextrin complexation. Chem Pharm Bull (Tokyo). 1986 Apr;34(4):1770-4. PubMed PMID: 3487392. 9: Yokoyama Y, Nakamura H. Effect of AD-1590, a non-steroidal anti-inflammatory agent with a potent antipyretic activity, on in vitro prostaglandin generation in rabbit brain. J Pharmacobiodyn. 1986 Apr;9(4):417-20. PubMed PMID: 3090227. 10: Takahashi T, Mori M, Uezono Y, Makita H, Nakanishi Y, Imasato Y. Influence of pharmaceutical properties on gastric lesions induced in rats by AD-1590, a non-steroidal anti-inflammatory drug. Chem Pharm Bull (Tokyo). 1986 Jan;34(1):308-14. PubMed PMID: 3486048. 11: Nakamura H, Yokoyama Y, Motoyoshi S, Seto Y, Kadokawa T, Shimizu M. Inhibition of prostaglandin generation in the rabbit brain in-vivo by AD-1590, a non-steroidal anti-inflammatory agent with potent antipyretic activity. J Pharm Pharmacol. 1985 Dec;37(12):894-8. PubMed PMID: 2868098. 12: Nakamura H, Yokoyama Y, Seto Y, Kadokawa T, Shimizu M. Central versus peripheral sites of antipyretic action of a non-steroidal anti-inflammatory agent, AD-1590, in rabbits. Agents Actions. 1984 Dec;15(5-6):606-11. PubMed PMID: 6335820. 13: Nakamura H, Yokoyama Y, Seto Y, Kadokawa T, Shimizu M. AD-1590, a potent antagonist of lipopolysaccharide-induced fever in rabbits. J Pharm Pharmacol. 1984 Mar;36(3):182-6. PubMed PMID: 6144753. 14: Nakamura H, Yokoyama Y, Motoyoshi S, Ishii K, Imazu C, Seto Y, Kadokawa T, Shimizu M. The pharmacological profile of 2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid (AD-1590), a new non-steroidal anti-inflammatory agent with potent antipyretic activity. Arzneimittelforschung. 1983;33(11):1555-69. PubMed PMID: 6607053.