MedKoo Cat#: 574686 | Name: EO-1428
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

EO-1428 is an inhibitor of p38α and p38β2 that inhibits production of inflammatory cytokines and displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

Chemical Structure

EO-1428
EO-1428
CAS# 321351-00-2

Theoretical Analysis

MedKoo Cat#: 574686

Name: EO-1428

CAS#: 321351-00-2

Chemical Formula: C20H16BrClN2O

Exact Mass: 414.0135

Molecular Weight: 415.71

Elemental Analysis: C, 57.78; H, 3.88; Br, 19.22; Cl, 8.53; N, 6.74; O, 3.85

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
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Synonym
EO 1428; EO-1428; EO1428; p38 MAP Kinase Inhibitor VIII
IUPAC/Chemical Name
(2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone
InChi Key
HDCLCHNAEZNGNV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H16BrClN2O/c1-12-4-2-3-5-15(12)20(25)16-8-7-14(11-17(16)22)24-19-9-6-13(21)10-18(19)23/h2-11,24H,23H2,1H3
SMILES Code
O=C(C1=CC=CC=C1C)C2=CC=C(NC3=CC=C(Br)C=C3N)C=C2Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 415.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1. Ottosen et al (2003) Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 46 5651 PMID: 14667219