IPL-344 | CAS# 877120-59-7 | Akt Activator

MedKoo Cat#: 576734 | Name: IPL-344

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PL344 is an Akt Activator. IPL344 is a novel peptide that reactivates the impaired Akt pathway without mediation of the cell membrane receptors that are damaged in ALS. Preclinical studies have demonstrated that IPL344 treatment improved neuro-muscular function in SOD1G93A ALS model mice, reduces weight loss and significantly extended their survival.

Chemical Structure

IPL-344

CAS#877120-59-7

Theoretical Analysis

MedKoo Cat#: 576734

Name: IPL-344

CAS#: 877120-59-7

Chemical Formula: C41H61N7O9

Exact Mass: 795.4531

Molecular Weight: 795.98

Elemental Analysis: C, 61.87; H, 7.72; N, 12.32; O, 18.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

IPL-344; IPL 344; IPL344

IUPAC/Chemical Name

L-Proline, L-leucyl-L-prolyl-L-prolyl-L-leucyl-L-prolyl-L-tyrosyl-

InChi Key

AGUSSGJBWOOHRG-NXBWRCJVSA-N

InChi Code

InChI=1S/C41H61N7O9/c1-24(2)21-28(42)37(52)47-19-7-11-33(47)40(55)46-18-6-10-32(46)36(51)43-29(22-25(3)4)38(53)45-17-5-9-31(45)35(50)44-30(23-26-13-15-27(49)16-14-26)39(54)48-20-8-12-34(48)41(56)57/h13-16,24-25,28-34,49H,5-12,17-23,42H2,1-4H3,(H,43,51)(H,44,50)(H,56,57)/t28-,29-,30-,31-,32-,33-,34-/m0/s1

SMILES Code

O=C(O)[C@H]1N(C([C@H](CC2=CC=C(O)C=C2)NC([C@H]3N(C([C@H](CC(C)C)NC([C@H]4N(C([C@H]5N(C([C@H](CC(C)C)N)=O)CCC5)=O)CCC4)=O)=O)CCC3)=O)=O)CCC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Akt activity has been shown to be down-regulated in post-mortem analysis of ALS patients motor neurons, as well as in neurons and muscles of ALS animal models. By activating the Akt pathway, treatment with IPL344 may address key ALS pathologies including apoptosis, cellular stress, protein misfolding, glucose metabolism and inflammation. IPL344 is a molecule that researchers designed to activate the Akt signaling pathway, which plays a role in the survival of cells. That pathway inhibits apoptosis, or naturally programmed cell death, and blocks inflammation in cells. Studies have shown that the activity of the Akt pathway is reduced in patients with ALS. By activating that pathway, researchers think that IPL344 may help protect nerve cells and slow the progression of the disease.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 795.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.