Synonym
Acrihellin; D 12316; D-12316; D12316;
IUPAC/Chemical Name
3beta,5,14-Trihydroxy-19-oxo-5beta-bufa-20,22-dienolide 3-(3-methylcrotonate)
InChi Key
RIOSSPWEPWYRLD-SBQWKNPYSA-N
InChi Code
InChI=1S/C29H38O7/c1-18(2)14-25(32)36-20-6-11-27(17-30)22-7-10-26(3)21(19-4-5-24(31)35-16-19)9-13-29(26,34)23(22)8-12-28(27,33)15-20/h4-5,14,16-17,20-23,33-34H,6-13,15H2,1-3H3/t20-,21+,22-,23+,26+,27-,28-,29-/m0/s1
SMILES Code
O=C(C=C1)OC=C1[C@H]2CC[C@]3(O)[C@]4([H])CC[C@]5(O)C[C@@H](OC(/C=C(C)\C)=O)CC[C@]5(C=O)[C@@]4([H])CC[C@]23C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
498.62
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Han DY. [Inhibitory effects of 6 cardiac glycosides on sodium pump in sheep Purkinje fibers]. Zhongguo Yao Li Xue Bao. 1994 May;15(3):244-9. Chinese. PubMed PMID: 7976380.
2: Herzig S, Lüllmann H, Mohr K, Seemann B. Acrihellin, a cardioactive steroid escaping from the organ-bath. Naunyn Schmiedebergs Arch Pharmacol. 1987 Mar;335(3):326-30. PubMed PMID: 3587374.
3: Stroman F, Jakovlev V, Metzenauer P, Roth E, Thiemer K. [The pharmacology of a new cardiosteroid, a partially synthetic derivative of the aglycone hellebrigenin (acrihellin)]. Arzneimittelforschung. 1984;34(7):769-79. German. PubMed PMID: 6541912.
4: Wiemer J, Achenbach C, Ziskoven R. Voltage clamp study of the action of the new cardiotonic compound acrihellin on fast and slow inward currents in cardiac Purkinje fibres. Arzneimittelforschung. 1983;33(10):1431-6. PubMed PMID: 6686042.
5: Achenbach C, Ziskoven R, Wiemer J. Effects of acrihellin on cardiac contractility in comparison to various inotropic interventions. Arzneimittelforschung. 1983;33(10):1425-30. PubMed PMID: 6686041.
6: Engel J, Isaac O, Posselt K, Thiemer K, Uthemann H. Synthesis of orally active cardiosteroid derivatives. Arzneimittelforschung. 1983;33(9):1215-8. PubMed PMID: 6685501.
7: Ziskoven R, Wiemer J, Achenbach C. The influence of a new cardiotonic drug, acrihellin, on sinus node and the current underlying pacemaker activity of cardiac Purkinje fibres. Arzneimittelforschung. 1983;33(8):1106-13. PubMed PMID: 6685487.
