MedKoo Cat#: 555254 | Name: J9
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

J9 is a Glucocorticoid resistance inhibitor. J9 Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL).

Chemical Structure

J9
J9
CAS#947018-15-7

Theoretical Analysis

MedKoo Cat#: 555254

Name: J9

CAS#: 947018-15-7

Chemical Formula: C12H12N4

Exact Mass: 212.1062

Molecular Weight: 212.26

Elemental Analysis: C, 67.90; H, 5.70; N, 26.40

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
1g USD 2,950.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
J9; J 9; J-9.
IUPAC/Chemical Name
4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
InChi Key
PQLYPFZAOUDDHB-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H12N4/c13-12-15-7-10(8-3-5-14-6-4-8)11(16-12)9-1-2-9/h3-7,9H,1-2H2,(H2,13,15,16)
SMILES Code
NC1=NC=C(C2=CC=NC=C2)C(C3CC3)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 212.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cantley AM, Welsch M, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A, Ferrando A, Stockwell BR. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). ACS Med Chem Lett. 2014 Apr 25;5(7):754-9. doi: 10.1021/ml500044g. eCollection 2014 Jul 10. PubMed PMID: 25050160; PubMed Central PMCID: PMC4094258.