Synonym
1-Tetralol, (S)-; (S)-Tetralin-1-ol; J330.337C; (S)-1-Hydroxytetralin;
IUPAC/Chemical Name
(S)-1,2,3,4-tetrahydronaphthalen-1-ol
InChi Key
JAAJQSRLGAYGKZ-JTQLQIEISA-N
InChi Code
InChI=1S/C10H12O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10-11H,3,5,7H2/t10-/m0/s1
SMILES Code
O[C@H]1CCCC2=C1C=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
148.20
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Świzdor A, Janeczko T, Dmochowska-Gładysz J. Didymosphaeria igniaria: a new microorganism useful for the enantioselective reduction of aryl-aliphatic ketones. J Ind Microbiol Biotechnol. 2010 Nov;37(11):1121-30. doi: 10.1007/s10295-010-0759-9. Epub 2010 Jun 11. PubMed PMID: 20544255.
2: Penick MA, Mahindaratne MP, Gutierrez RD, Smith TD, Tiekink ER, Negrete GR. Tandem Friedel-Crafts annulation to novel perylene analogues. J Org Chem. 2008 Aug 15;73(16):6378-81. doi: 10.1021/jo800558c. Epub 2008 Jul 16. PubMed PMID: 18630879; PubMed Central PMCID: PMC4780845.
3: Bichlmaier I, Siiskonen A, Kurkela M, Finel M, Yli-Kauhaluoma J. Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17. Biol Chem. 2006 Apr;387(4):407-16. PubMed PMID: 16606339.
4: Gee CL, Tyndall JD, Grunewald GL, Wu Q, McLeish MJ, Martin JL. Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis. Biochemistry. 2005 Dec 27;44(51):16875-85. PubMed PMID: 16363801.
5: Fujio M, Keeffe JR, More O'Ferrall RA, O'Donoghue AC. Unexpectedly small ortho-oxygen substituent effects on stabilities of benzylic carbocations. J Am Chem Soc. 2004 Aug 18;126(32):9982-92. PubMed PMID: 15303872.
6: Jung JC, Kim JC, Park OS, Jang BS. Synthesis of 4-hydroxy-1-thiocoumarin derivatives-1: an efficient synthesis of thioflocoumafen. Arch Pharm Res. 1999 Jun;22(3):302-5. PubMed PMID: 10403135.
7: Grayson DA, Tewari YB, Mayhew MP, Vilker VL, Goldberg RN. Tetralin as a substrate for camphor (cytochrome P450) 5-monooxygenase. Arch Biochem Biophys. 1996 Aug 15;332(2):239-47. PubMed PMID: 8806731.
8: Grunewald GL, Ye Q, Sall DJ, Criscione KR, Wise B. Conformational and steric aspects of phenylethanolamine and phenylethylamine analogues as substrates or inhibitors of phenylethanolamine N-methyltransferase. Mol Pharmacol. 1989 Jan;35(1):93-7. PubMed PMID: 2913486.
9: Grunewald GL, Ye QH. Stereochemical aspects of phenylethanolamine analogues as substrates of phenylethanolamine N-methyltransferase. J Med Chem. 1988 Oct;31(10):1984-6. PubMed PMID: 3172133.
10: Matos FF, Lippman DA, Malone MH. Opioid receptor effects of two 3-amino-2,2-dimethyltetralin analogs in guinea pig ileum longitudinal muscle. NIDA Res Monogr. 1986;75:217-9. PubMed PMID: 3123938.