2',3'-Dialdehyde ATP| CAS#54970-91-1 | irreversible inhibitor

MedKoo Cat#: 111008 | Name: 2',3'-Dialdehyde ATP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2',3'-Dialdehyde ATP is a derivative of, and the oxidized form of, ATP. It has been found to be a specific, irreversible inhibitor of component A3 of the methylreductase system which plays a role in processing amino acids.

Chemical Structure

2',3'-Dialdehyde ATP

CAS# 54970-91-1

Theoretical Analysis

MedKoo Cat#: 111008

Name: 2',3'-Dialdehyde ATP

CAS#: 54970-91-1

Chemical Formula: C10H14N5O13P3

Exact Mass: 504.9801

Molecular Weight: 505.17

Elemental Analysis: C, 23.78; H, 2.79; N, 13.86; O, 41.17; P, 18.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Adenosine 5'-triphosphate; 2',3',-dialdehyde ATP Dialdehyde; Dial-ATP; oATP; OATP (oxidized adenosine triphosphate); Oxidized ATP; Oxo-ATP

IUPAC/Chemical Name

P-(2-(1-(6-amino-9H-purin-9-yl)-2-oxoethoxy-3-oxopropyl)) ester

InChi Key

ZOSTZYMLOPBGQI-NKWVEPMBSA-N

InChi Code

InChI=1S/C10H14N5O13P3/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t6-,7+/m0/s1

SMILES Code

Nc1ncnc2c1ncn2[C@H](O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C=O)C=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 505.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Chen HB, Lin YH, Sun SH. Oxidized ATP decreases beta-actin expression and intracellular superoxide concentrations in RBA-2 type-2 astrocytes independently of P2X7 receptor. Eur J Pharmacol. 2006 Nov 21;550(1-3):1-7. doi: 10.1016/j.ejphar.2006.08.039. Epub 2006 Sep 5. PMID: 17020759. 2. Wu PY, Lin YC, Chang CL, Lu HT, Chin CH, Hsu TT, Chu D, Sun SH. Functional decreases in P2X7 receptors are associated with retinoic acid-induced neuronal differentiation of Neuro-2a neuroblastoma cells. Cell Signal. 2009 Jun;21(6):881-91. doi: 10.1016/j.cellsig.2009.01.036. PMID: 19385050. 3. Lang PA, Merkler D, Funkner P, Shaabani N, Meryk A, Krings C, Barthuber C, Recher M, Brück W, Häussinger D, Ohashi PS, Lang KS. Oxidized ATP inhibits T-cell-mediated autoimmunity. Eur J Immunol. 2010 Sep;40(9):2401-8. doi: 10.1002/eji.200939838. PMID: 20683833. 4. Schachter J, Valadao AL, Aguiar RS, Barreto-de-Souza V, Rossi AD, Arantes PR, Verli H, Quintana PG, Heise N, Tanuri A, Bou-Habib DC, Persechini PM. 2´,3´-Dialdehyde of ATP, ADP, and adenosine inhibit HIV-1 reverse transcriptase and HIV-1 replication. Curr HIV Res. 2014;12(5):347-58. doi: 10.2174/1570162x12666140826105824. PMID: 25174839.