Synonym
12 epi Napelline; 12epi Napelline; 12-epi Napelline; 12-Epinapelline; 12Epinapelline; 12 Epinapelline
IUPAC/Chemical Name
(3R,6S,6aS,6bR,8R,9R,11R,11aR,12R,12aR,14R)-1-ethyl-3-methyl-10-methylenetetradecahydro-3,6a,12-(epiethane[1,1,2]triyl)-9,11a-methanoazuleno[2,1-b]azocine-6,8,11-triol
InChi Key
AZAZKLKDEOMJBJ-PQNIRSBSSA-N
InChi Code
InChI=1S/C22H33NO3/c1-4-23-10-20(3)6-5-17(25)22-15(20)7-13(18(22)23)21-9-12(11(2)19(21)26)14(24)8-16(21)22/h12-19,24-26H,2,4-10H2,1,3H3/t12-,13+,14-,15-,16-,17+,18-,19-,20+,21+,22-/m1/s1
SMILES Code
O[C@@H]1[C@@]23[C@]4([C@@]5([C@@H]6[C@]2(N(CC)C[C@@](CC1)(C)[C@H]3C6)[H])C[C@@H]([C@H](O)C4)C([C@H]5O)=C)[H]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Chloroform |
10.0 |
27.82 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
359.51
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Nesterova YV, Povet'yeva TN, Suslov NI, Zyuz'kov GN, Pushkarskii SV, Aksinenko SG, Schultz EE, Kravtsova SS, Krapivin AV. Analgesic activity of diterpene alkaloids from Aconitum baikalensis. Bull Exp Biol Med. 2014 Aug;157(4):488-91. doi: 10.1007/s10517-014-2598-6. Epub 2014 Aug 12. PMID: 25110090.
2: Nesterova YV, Povetieva TN, Suslov NI, Zyuz'kov GN, Aksinenko SG, Pushkarskii SV, Krapivin AV. Anti-inflammatory activity of diterpene alkaloids from Aconitum baikalense. Bull Exp Biol Med. 2014 Mar;156(5):665-8. doi: 10.1007/s10517-014-2421-4. Epub 2014 Mar 30. PMID: 24770754.
3: Nesterova YV, Povetieva TN, Suslov NI, Zhdanov VV, Hrichkova TY, Udut EV, Chaykovskiy AS, Gaydamovich NN, Andreeva TI, Dygai AM. Regeneratory characteristics of complex extract and isolated diterpene alkaloids of Aconitum baikalense. Bull Exp Biol Med. 2012 Feb;152(4):439-43. English, Russian. doi: 10.1007/s10517-012-1548-4. PMID: 22803106.
